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Advanced Biomanufacturing of Therapeutic Cells (ABTC)
In recent years, somatic cells as therapeutic agents have provided new treatment approaches for a number of pathological conditions that were deemed untreatable, or difficult to treat. Several successful cell therapies using T cells have been demonstrated for cancer and autoimmune diseases, while stem cell therapies have given relief for heart disease and stroke. Hundreds of clinical trials are ongoing to examine efficacy of cell therapies for a variety of other diseases including diabetes, Alzheimer’s, Parkinson’s, and Crohn’s disease. Production of therapeutic cells is currently expensive and, therefore, cost prohibitive for the large number of people who might benefit from these treatments. The overarching goal of this Advanced Biomanufacturing of Therapeutic Cells (ABTC) solicitation is to catalyze well-integrated interdisciplinary research to understand, design, and control cell manufacturing systems and processes that will enable reproducible, cost-effective, and high-quality production of cells with predictable performance for the identified therapeutic function.
Preliminary Proposal Due Date(s) (required) (due by 5 p.m. submitter's local time): January 04, 2017
Invited Full Proposal Deadline(s) (due by 5 p.m. submitter's local time): April 17, 2017
An individual may appear as PI, co-PI, other senior personnel, or consultant on no more than two preliminary proposals or proposals submitted in response to this solicitation. This limitation includes preliminary proposals or proposals submitted by a lead organization or any sub-award submitted as part of a preliminary proposal or proposal. Please be advised that if an individual's name appears, in any capacity, on more than TWO preliminary proposals or proposals, all submittals after the first two preliminary proposals or proposals (based on the time-stamp) will be returned without review.