Advancing Genomic Medicine Research (R01, R03, R21 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This NOFO solicits proposals that stimulate innovation and advance understanding of when, where, and how best to implement the use and sharing of genomic information and technologies in clinical care  provided to all persons irrespective of racial/ethnic background or socioeconomic status.

Plan for Enhancing Diverse Perspectives 

The NIH recognizes that diverse teams working together and capitalizing on innovative ideas and distinct perspectives outperform homogeneous teams. There are many benefits that flow from a diverse scientific workforce, including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, advancing the likelihood that underserved populations participate in, and benefit from research, and enhancing public trust. To support the best science, the NIH encourages inclusivity in research. Examples of structures that promote diverse perspectives include but are not limited to: 

  • Transdisciplinary research projects and collaborations among neuroscientists and researchers from fields such as computational biology, physics, engineering, mathematics, computer and data sciences, as well as bioethics.
  • Engagement from different types of institutions and organizations (e.g., research-intensive, undergraduate-focused, minority-serving, community-based). 
  • Individual applications and partnerships that enhance geographic and regional heterogeneity. 
  • Investigators and teams composed of researchers at different career stages. 
  • Participation of individuals from diverse backgrounds, including groups traditionally underrepresented in the biomedical, behavioral, and clinical research workforce (see NOT-OD-20-031), such as underrepresented racial and ethnic groups, those with disabilities, those from disadvantaged backgrounds, and women. 
  • Opportunities to enhance the research environment to benefit early- and mid-career investigators. 

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with two program announcements of identical scientific scope, RFA-HG-23-033, which uses the R21 grant mechanism, and RFA-HG-23-048 , which uses the R03 grant mechanism. 


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): Dec. 1, 2023; July 8, 2024; Feb. 11, 2025

RFA-HG-23-032 Expiration Date February 12, 2025

Agency Website



Amount Description

Application budgets are limited to $500K d irect costs per year and should reflect the actual needs of the proposed project.

Budgets should include any funds required to support sharing of scientific data under this NOFO. NIH provides guidance on allowable costs for data management and sharing here. For projects generating genomic data derived from research participants, investigators should consider costs associated with complying with the NIH and NHGRI GDS Policy expectations (e.g., obtaining samples with explicit informed consent for future research use and broad data sharing, implementing processes to seek new consent from study participants, etc.). 

Funding Type





Medical - Basic Science
Medical - Clinical Science

External Deadline

July 8, 2024