Advancing Research on Mechanisms and Management of Pain for Diseases and Conditions within NIDDK Mission Areas (R01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The impact of pain on patient quality of life for diseases and conditions within the mission of the NIDDK is enormous. Despite prior research efforts, our understanding of the underlying biological and clinical contributors of pain remains limited. In addition, new clinical management strategies for pain that better measure, predict, and target pain and improve upon current interventions, such as opioids, are critically needed. The current Funding Opportunity Announcement will address these needs through the invitation of broad investigator-initiated research projects proposing novel basic, translational, and clinical studies and efforts to develop new approaches to assess and treat pain for disorders within the NIDDK's mission. Investigations are expected to provide important new insights into the pathophysiology and clinical features of pain and foster new and improved treatment and pain management strategies for patients.


  • Letter of Intent: April 4, 2023
  • Application: May 4, 2023

RFA-DK-23-006 Expiration Date May 05, 2023

Agency Website

Amount Description

Application budgets may request a maximum of $750,000 direct costs per year. It is anticipated awards will be made through multi-year funding and encompass the approved total costs for the entire awarded project period. Funds beyond the first year will initially be restricted. Respective funds will be released each non-competing year per the terms of the Notice of Grant Award.

The maximum project period is 3 years.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 4, 2023