Advancing Research Solutions to CLAD Award

Funding Agency:
Cystic Fibrosis Foundation

The Cystic Fibrosis Foundation has started a lung transplant initiative to address the unmet needs of people with cystic fibrosis with advanced lung disease. The mission of this initiative is to improve the care and long-term outcomes of individuals with CF with advanced lung disease. 

The Advancing Research Solutions to Chronic Lung Allograft Dysfunction (CLAD) award is intended to improve our understanding of the mechanism(s) of lung transplant rejection and identify approaches to improve survival in people with CF post-lung transplant.  

Deadlines:

  • Required Letter of Intent Deadline: July 10, 2018
  • Application Deadline: Sep. 24, 2018

Agency Website

Areas of Interest

Areas of interest include, but are not limited to, the following:

  • Endotyping of CLAD
  • Understanding CLAD pathogenesis with the aim of ultimately identifying new therapeutic targets
  • Developing technologies, testing modalities, and model systems for diagnosing CLAD early and monitoring CLAD progression
  • Clarifying the role of the microbiome and CF pathogens in the development of CLAD
  • Exploring transplant immunology, including immunophenotyping, cellular and humoral immune changes corresponding to lung infections after lung transplantation, and therapeutic uses of immune cells

A goal of this request for applications (RFA) is to promote collaboration between investigators with complementary expertise and/or shared knowledge and common resources. Larger funded research awards are available for collaborative proposals, which are encouraged. 

Eligibility Requirements

  • Collaborative research awards will be considered for funding up to $350,000 per year for up to two years, plus 8 percent indirect costs to support integrated, multiple independent investigator projects collaborating around a common theme or topic.
  • One application is required for each collaborative project. A principal investigator (PI) must submit one application on behalf of all participating PIs, and the budget must include a lead site with the other participating sites as subcontractors.
  • Collaborative research awards may be considered for renewal for a third year of funding after the initial funding cycle based on progress toward achieving the aims of the project and the availability of funds.
  • Funding for independent smaller research awards up to $150,000 per year for up to two years, plus 8 percent indirect costs will be considered.
  • U.S. residents and international applicants are welcome to apply.

Amount

$700,000

Funding Type

Award

Eligibility

Faculty
Junior Faculty

Category

Medical
Medical - Basic Science
Medical - Clinical Science

External Deadline

July 10, 2018