Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) and National Institute on Aging (NIA) will promote research to advance the understanding of the mechanistic factors and cellular interactions during aging that contribute to cancer initiation. Collaborations are strongly encouraged between scientists in the fields of aging biology and cancer biology. Applications should address key questions regarding how hallmarks of aging that lead to impaired cellular activities (metabolic alterations, proteostasis, epigenetic changes, and DNA repair) and alterations in the microenvironment (inflammation and immunosenescence) contribute to the development and outgrowth of cancer-initiating cells.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date(s): October 27, 2020; February 17, 2021

RFA-CA-20-040 Expiration Date February 18, 2021

Agency Website



Amount Description

Award budgets are limited to $300,000 per year in direct costs and must reflect the actual needs of the proposed project.

The maximum project period is up to 5 years.

Funding Type





Environmental & Life Sciences
Medical - Basic Science

External Deadline

February 17, 2021