Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R21 - Clinical Trial Optional)

Funding Agency:
National Institutes of Health

 The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC), in collaboration with the International IBD Genetics Consortium, has identified about 200 susceptibility loci for IBD.  The IBDGC has recently been awarded renewed funding to identify causal genes and genetic variants within these loci, and to elucidate the mechanisms through which they contribute to the pathophysiology of IBD.  However, the IBDGC's current resources permit them to explore the functions of only a limited set of genes within a limited set of physiological domains.  The purpose of this Funding Opportunity Announcement (FOA) is to expand the number of genes and range of IBD-related phenotypes and physiological domains under study by means of collaborations of the IBDGC with investigators with expertise complementary to that of their own members.  This FOA is intended to support highly exploratory studies which may require development and testing of novel experimental platforms or analytic methods.  Proposed studies must not duplicate studies either ongoing or already completed by the IBDGC.  Multi-site clinical trials will not be considered responsive to this FOA.

Only one application per institution is allowed.


  • Duke Internal Deadline: November 20, 2019
  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s):  February 21, 2020

RFA-DK-17-018 Expiration Date February 22, 2020

If the internal deadline has passed and you are interested in this opportunity, please email Anastasia Maddox at to find out if it is still open.


Agency Website

Eligibility Requirements

 Individuals receiving salary from any cooperative agreement awarded under RFA-DK-16-029 are not eligible to serve as PDs/PIs although they may serve as Senior/Key Personnel or Other Significant Contributors.



Amount Description

Application budgets are limited to $275,000 direct costs for two years with a maximum of $150,000 allowed in any year.

    Funding Type





    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    Internal Nomination

    Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

    A letter of support from dean or chair - 1 to 1.5 pages
    Project Summary/Abstract – 30 lines of text
    Project Narrative – three sentences
    Specific Aims – 1 page
    * NIH Biosketch of project leader

    Please submit internal materials through My Research Proposal. (Code ILN)

    Instructions for creating an account (if needed) and submitting your materials:

    Internal Deadline

    November 20, 2019

    External Deadline

    February 21, 2020