This funding opportunity annoucement (FOA) seeks applications for a Coordinating Center that will support the activities of a cooperative multi-site Acute Respiratory Distress Syndrome (ARDS), Pneumonia, and Sepsis Phenotyping Consortium (APS Consortium). The APS Consortium will seek to understand the heterogeneity and underlying mechanisms of critical illness syndromes and recovery, specifically in adults with ARDS, pneumonia, and/or sepsis, as well as the relationship and biological overlap among these syndromes. This will be accomplished through a prospective, longitudinal observational study with common data and biospecimen collection of 5,000 hospitalized adults with one or more of the following diagnoses: ARDS, pneumonia, or sepsis. It is expected that approximately half of the participants discharged from the hospital will have follow-up at 3, 6, and 12 months to facilitate understanding of long-term outcomes, including biological and physiological resolution of ARDS, pneumonia, and sepsis. Throughout the program’s funding period, data (including imaging data) and biospecimens collected will be made available as a resource to the broader research community as rapidly and simply as possible.
The Coordinating Center will be expected to have expertise in statistics, longitudinal cohort studies, informatics, data management (including imaging data), and biospecimen management, and to have demonstrable interest in developing proactive policies for sharing.
This FOA runs in parallel with the APS Consortium Clinical Centers (see RFA-HL-23-001).
Deadlines:
- Letter of Intent: May 17, 2022
- Application: June 17, 2022
RFA-HL-23-002 Expiration Date June 18, 2022
NHLBI encourages multi-PD/PI applications with at least two PDs/PIs; one a senior statistician with demonstrated experience in coordinating large multi-site clinical research studies and another senior investigator with extensive clinical research experience and expertise in the areas of ARDS, pneumonia, and/or sepsis. Familiarity with and support for data and biospecimen collection for sharing purposes is desirable.
Application budgets are limited to $975,000 in year 1 and $1,275,000/year in years 2-6 in direct costs, but should reflect the actual needs of the project.
In addition, patient care funds of $780,000 in year 1 and $4,680,000/year in years 2-5 will be included in the Coordinating Center award and will be distributed to Clinical Centers in accordance with the Steering Committee and NHLBI-approved budget for the Consortium-wide longitudinal cohort study.