Basic and Translational Research on Decision Making in Aging and Alzheimer's Disease (R01, R21 - Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This funding opportunity announcement (FOA) invites applications for basic research to better characterize the affective, cognitive, social, and motivational parameters of impaired and intact decision making in both normal aging and Alzheimer's disease (AD). Research is sought that will characterize the extent to which basic behavioral and neural processes involved in decision making are differentially impacted in normal aging and AD, investigate the influence of social factors on decision making, and investigate the decision-making factors that render older adults (with or without cognitive impairment) vulnerable to financial exploitation and other forms of mistreatment and abuse.

The FOA also invites applications to apply basic research on the processes involved in decision making to the design of decision-supportive interventions for midlife and older adults with and without AD. Specific opportunities include the development of decision-supportive interventions to leverage cognitive, emotional and motivational strengths of these populations; tools to assess decisional capacity; strategies for simplifying choices and offering better defaults; and the promotion of timely adoption of optimal delegation practices (e.g., power of attorney, living wells, etc.).

Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with a program announcement of identical scientific scope. PAR-18-538, which uses the R21 exploratory/developmental grant mechanism.


  • R01 Due Dates: The first application due date is March 29, 2018. Subsequent due dates are June 8, 2018; February 8, 2019; June 8, 2019; February 7, 2020; and July 8, 2020.
  • R21 Due Dates: The first application due date is March 29, 2018, by 5:00 PM local time of the applicant organization. Subsequent due dates are June 20, 2018; February 20, 2019; June 20, 2019; February 20, 2020; and July 22, 2020

PAR-18-544 Expiration Date New Date July 9, 2020 per issuance of NOT-AG-20-030. (Original Expiration Date: June 9, 2020)




Medical - Basic Science
Medical - Translational

External Deadline

July 8, 2020