Funding Agency:
Chan Zuckerberg Initiative

The Chan Zuckerberg Initiative invites applications to join the CZI Neurodegeneration Challenge Network, an interdisciplinary collaborative initiative to increase understanding of the fundamental biology of neurodegenerative disorders. Applications are being accepted for two funding mechanisms:

  1. CZI Ben Barres Early Career Acceleration Awards: investigator awards for early career academic investigators, especially those who are new to the field of neurodegeneration
  2. CZI Collaborative Science Awardsawards for small group interdisciplinary collaborations that include a physician with active clinical engagement

The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers.

This is explicitly not a translational or clinical development RFA and rather is aimed at foundational and mechanistic studies. Nonetheless, successful projects should be grounded in human biology and disease pathology, and the goal is that these efforts will ultimately provide new avenues and rigorous foundations for other translational and clinical development work.

We encourage applications both from investigators who are tackling underexplored topics, as well as those addressing more well-developed mechanisms where there remain significant gaps in understanding.


  • Collaborative Science Award: Required Letter of Intent due April 3, 2018
  • Early Career Awards: April 17, 2018

Agency Website

Eligibility Requirements

  • Applicants may only apply for one program in the Neurodegeneration Challenge Network. If you are applying for a CZI Collaborative Science Award, you may not apply for a CZI Ben Barres Early Career Acceleration Award. If you apply for a CZI Ben Barres Early Career Acceleration Award, you may not apply for a CZI Collaborative Science Award.

Amount Description

Early Career Award: $500K total costs per year for five years, for a total of $2.5M (including up to 15% indirect costs).

Collaborative Science Award: $350,000 total costs per year for three years for a total of $1,050,000 total costs for the project

Funding Type



Junior Faculty
Women and minorities encouraged


Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

April 3, 2018