Biologic Factors Underlying Dental, Oral, and Craniofacial Health Disparities (R01 - Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to support investigator-initiated studies designed to identify and understand biologic factors (microbial, immune, genetic) that contribute to disparities in dental, oral, and craniofacial disease onset, progression, and persistence.

Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-18-874, which uses the R21 grant mechanism.


  • R01 Due Date(s): Feb. 5, Jun. 5, Oct. 5
  • R21 Due Dates: Feb. 16, Jun. 16, Oct. 16
  • AIDS Due Date(s): Jan. 7, May 7, Sep. 7

PAR-18-875 Expiration Date September 8, 2021

Agency Website

Areas of Interest

The scope of this FOA includes but is not limited to, research on:

    • Microbial and inflammatory mediators of oral diseases in different racial/ethnic groups, and their contribution to racial/ethnic differences in disease prevalence, severity and/or outcomes.
    • The biologic responses to social, environmental, behavioral, cultural, and socioeconomic factors that contribute to oral health disparities.
    • Research defining mechanisms by which social factors lead to biologic changes that affect health disparities
    • Biologic responses to conventional therapy for dental, oral, and craniofacial diseases that may explain the persistence of these diseases in different health disparities populations.
    • Genetic/genomic risk or protective factors that might contribute to racial/ethnic differences in dental caries and periodontal diseases, and the interplay with other factors.
    • Genetic/genomic risk factors that could contribute to poorer health outcomes among various health disparity populations with oral and oropharyngeal cancers.

Amount Description


Funding Type





Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

June 5, 2021