Biological Measures for Prognosing and Monitoring of Persistent Concussive Symptoms in Early and Middle Adolescents: Center Without Walls (PCS-EMA CWOW) (U54 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) is to promote the development and initial clinical validation of objective biological measures to be used for prognosing, and monitoring recovery of adolescents who either clinically present with or are at risk for developing prolonged/persistent concussive symptoms following exposure to repetitive head impacts and/or concussion. 

Resultant biological measures should be incorporated into risk stratification algorithms to inform clinical care and patient stratification for future clinical trials.  A critical feature of this FOA includes the broad sharing of clinical, neuroimaging, physiological, and biospecimen data to further advance research in the area of persistent concussive symptoms in early and middle adolescent (EMA; ages 11-17 years old) populations.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): June 26, 2020  ​

RFA-NS-20-016 Expiration Date June 27, 2020

Agency Website



Amount Description

Application budgets are limited to $2,000,000 direct costs per year but need to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.      

        Funding Type





        Environmental & Life Sciences
        Medical - Basic Science
        Medical - Clinical Science
        Medical - Translational

        External Deadline

        June 26, 2020