The Biological Mechanisms of Metformin Effects on Aging and Longevity (R01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This FOA invites applications on novel studies of the molecular mechanisms underlying metformin’s effects on aging and longevity. The goal of this FOA is to support applications that will lead to an in-depth understanding of the molecular mechanisms that determine the effects of metformin, either beneficial or detrimental, in relation to aging and longevity. Research supported by this FOA should lead to new insights on and better understanding of metformin’s effects on aging and aging-related diseases.


  • Letter of Intent Due Date(s): December 21, 2019
  • Application Due Date(s): January 21, 2020

RFA-AG-20-044 Expiration Date January 22, 2020

Agency Website



Amount Description

Applications budgets should not exceed $250,000 per year in direct costs.
The maximum project period is 5 years.

Funding Type





Environmental & Life Sciences
Medical - Basic Science

External Deadline

January 21, 2020