Biological Technologies Office -- ADvanced Acclimation and Protection Tool for Environmental Readiness (ADAPTER)

Funding Agency:
Defense Advanced Research Projects Agency

The Biological Technologies Office (BTO) is soliciting innovative proposals to enable the development of hybrid technology (bioelectronics and synthetic biology) for warfightercontrolled, on-demand enhanced management of circadian rhythms and mitigation of gastrointestinal stress caused by pathogenic bacteria. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in incremental improvements to the existing state of practice.

The ADvanced Acclimation and Protection Tool for Environmental Readiness (ADAPTER) program will develop a travel adapter for the human body, an implantable or ingestible bioelectronic carrier that contains therapeutic cellular factories and biomolecules which can provide warfighters control over their own physiology. The integrated system will house multiple capabilities that typically require lengthy preparation or cold chains such as instant antibiotic production, in vivo toxin removal from ingested resources, and enhanced warfighter acclimation to jet lag or shift lag. It will alleviate operational limitations imposed by human physiology for two high-priority military needs: (1) entraining the sleep cycle, either to a new time zone or back to a normal sleep pattern after night missions; and (2) eliminating bacteria that cause traveler’s diarrhea, a perennial challenge for militaries noted as far back as the Peloponnesian War. ADAPTER will provide a transient, non-genetic means of extending and enhancing warfighter readiness.



o Proposal Abstract Due Date and Time: April 29, 2020, 4:00 PM ET

o Full Proposal Due Date and Time: June 18, 2020; 4:00 PM ET

Agency Website

Areas of Interest

Technical Area 1: Accurate Therapies

Technical Area 2: Carrier and Communication

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Clinical Science
Medical - Translational

External Deadline

June 18, 2020