The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.
Deadlines:
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Letter of Intent Due Date(s): 30 days prior to the application due date
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Application Due Date(s): August 10, 2021, February 9, 2022, August 9, 2022, February 9, 2023, August 9, 2023, February 9, 2024; July 15, 2024
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AIDS Application Due Date(s): September 5, 2021, April 5, 2022, September 5, 2022, April 5, 2023, September 5, 2023, April 5, 2024; August 19, 2024
PAR-21-233 Expiration Date New Date August 20, 2024 (Original Date: April 06, 2024) per issuance of NOT-NS-24-050
Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity.
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Applicants should rarely exceed up to $500,000 total cost per year for Phase I and up to $1,500,000 total cost per year for the Phase II. In all cases, applicants should propose a budget that is reasonable and appropriate for completion of the research project. Application budgets should only cover the work that will be performed by the PD/PI and his/her staff. The NIH will pay BPN contractors and consultants directly for their work; therefore, these expenses should not be included in the budget for this application.