Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

Companion FOAs:

PAR-20-111 , U44 Small Business Innovation Research (SBIR) Cooperative Agreements - Fast-Track
PAR-20-122 , UG3UH3 Phase 1 Exploratory/Developmental Cooperative Agreement/Exploratory/Developmental Cooperative Agreement Phase II

Deadlines:

  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Dates: Aug 10, 2021; Feb 9, 2022; Aug 9, 2022; Feb 9, 2023; Aug 9, 2023; Feb 9, 2024; July 15, 2024

  • AIDS Due Dates: Sep 7, 2021; May 7, 2022; Sep 7, 2022; May 7, 2023; Sep 7, 2023; May 7, 2024; Aug 19, 2024

PAR-21-163 Expiration Date New Date August 20, 2024 (Original Date: May 08, 2024) per issuance of NOT-NS-24-049

Eligibility

Faculty

Category

Engineering and Physical Sciences
Environmental & Life Sciences
Medical
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

July 15, 2024