Botanical Dietary Supplements Research Centers (BDSRC) (U19 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This funding opportunity announcement (FOA), for one component of the NIH Consortium for Advancing Research on Botanicals and other Natural Products (CARBON) Program, represents an evolution of the previous Botanical Dietary Supplements Research Centers FOA, RFA OD 14-001. The goal of the consortium is to advance methodology for, and conduct research on, complex natural products. This Botanical Dietary Supplements Research Centers (BDSRC) component of the CARBON will support transdisciplinary collaborations focused on producing the most critical data to inform the optimal design of future clinical trials of orally consumed, complex botanical dietary supplements for which there are rigorous but not definitive preliminary data. The preliminary data provided by responsive applications must support a reproducible, physiologically and mechanistically plausible, and statistically and clinically significant effect on, or relevant to, human biological or cognitive/behavioral, objectively measured resilience. Applications in which a purified phytochemical is the main focus will be considered nonresponsive. Achievement of the BDSRC Specific Aims is expected to contribute critical information for the design of optimally informative clinical trials. Results from the BDSRC might, for example, be targeted to inform decisions related to specific trial design, product formulation(s), doses, timing, eligibility criteria, data to be collected, markers of proximal biological effect, outcome measures, etc. This FOA cannot, itself, be used to support clinical trials of efficacy or effectiveness. Applications proposing such trials will be considered nonresponsive. Each BDSRC will be required to include a Botanical Research Core, two research projects that synergize with each other and with the Core, and plans for supporting research training.

Only one application per institution is allowed.

Companion FOAs: 

RFA-AT-19-002U24 Resource-Related Research Projects – Cooperative Agreement

RFA-AT-19-003U41 Biotechnology Resource Cooperative Agreements


  • Duke Internal: February 21, 2019 March 21, 2019
  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): April 15, 2019

RFA-AT-19-001 Expiration Date April 16, 2019

If the internal deadline has passed and you are interested in this opportunity, please email Anastasia Maddox at to find out if it is still open.

Agency Website



Amount Description

Application budgets are limited to $1.2 million total costs per year, but need to reflect the actual needs of the proposed project. F&A on consortia must be included within the $1.2 million total costs.

 The scope of the proposed project should determine the project period. The maximum project period is 5 years.

    Funding Type





    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    Internal Nomination

    Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

    A letter of support from dean or chair - 1 to 1.5 pages
    NIH Biosketch of project leader
    Draft of the following:
        Project Summary/Abstract – 30 lines of text
        Project Narrative – three sentences
        Specific Aims – 1 page

    Please submit internal materials through My Research Proposal. (Code ILN)

    Instructions for both creating an account (if you don't already have one) and submitting your materials can be found here:

    Internal Deadline

    March 21, 2019

    External Deadline

    April 15, 2019