BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) intends to support cloud-based common imaging data processing pipelines to uniformly process high-volume imaging-based brain cell atlas data. The purpose is to visualize, register, analyze, and integrate the cell atlas imaging data, and characterize molecular and anatomical phenotypes and features of brain cells. The overall goals of Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data Findable, Accessible, Interoperable, and Reusable (FAIR), and the process transparent. An application is expected to propose only one of the above four respective elements.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date: Feb. 1, 2023

RFA-MH-22-291 Expiration Date February 02, 2023

Agency Website

Areas of Interest

The BICAN will be made up of interactive projects with complementary roles from the following funding oppourtunities:

  • Comprehensive Centers on Human and Non-human Primate Brain Cell Atlases (UM1; RFA-MH-21-235): The UM1 centers will have the primary responsibility for generating comprehensive and high-resolution brain cell atlas data in human and non-human primates.
  • Specialized Collaboratories on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01; RFA-MH-21-236): The U01 Collaboratories will complement and enhance the UM1 Centers with distinct capabilities, competencies, and research aims in creating comprehensive and high-resolution brain cell atlases.
  • Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24; RFA-MH-21-237): The U24 CUBIE will coordinate BICAN operation and establish common data analysis pipelines and knowledgebase of brain cell types.
  • BRAIN Initiative Data Archives (R24; RFA-MH-20-600): The R24 Data Archives will serve as BICAN data repositories and provide public access to all data and analyses generated by the BICAN.
  • Scalable Technologies and Tools Projects (R01; RFA-MH-21-140): The R01 projects will provide leading-edge scalable technologies and tools to enhance the productivity of the BICAN.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

February 1, 2023