BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support dissemination facilities for scaled-up production and distribution of a specific set of brain cell type-specific access reagents to study circuit function. Production and Distribution Facilities will be supported to disseminate hundreds of reagents specifically from Reagent Resource for Design and Development projects developed under RFA-MH-25-100. This NOFO will support facilities to interface with these specific reagent development projects, scale up reagent production, disseminate reagents broadly, and coordinate reagent data distribution.  The types of reagents to be produced and distributed could include but are not limited to viral vectors, nucleic acid constructs, and nanoparticles designed for selective access to hundreds of brain cell types. Such reagents will enable neuroscientists to probe circuit function with high precision in experimental animals and ex vivo human tissue and cells. Facilities are needed to contribute to the production and distribution of reagents broadly to neuroscience researchers. This NOFO is part of the BRAIN Initiative Armamentarium project, whose overall goal is to generate tools to specifically access, manipulate, and monitor brain cell types across multiple vertebrate species.  This NOFO will foster close interaction between technologists, disseminators, and neurobiologists in a research consortium including investigators funded by other Armamentarium NOFOs.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation.  Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

Applicants are strongly encouraged to read the FOA instructions carefully and view the available PEDP guidance material.

Deadlines:

  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date(s): Oct. 31, 2025; July 1, 2026

RFA-MH-25-105 Expiration Date July 02, 2026

Agency Website

Amount Description

Issuing IC and partner components intend to commit an estimated total of $2,400,000 per year to fund 2 to 4 awards.

Application budgets are not limited but need to reflect the actual needs of the proposed project.

Funding Type

Grant

Eligibility

Faculty

Category

Interdisciplinary
Medical
Medical - Basic Science
Medical - Clinical Science

External Deadline

October 31, 2025