Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01)

Funding Agency:
National Institutes of Health

This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders.  This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational, single-cell and other relevant approaches.  Awards made under this FOA and the companion FOA (PAR-14-173) will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data.  The ultimate goal of this FOA and the companion FOA (PAR-14-173) is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders.

This FOA should be used when two or more collaborating sites are essential to complete the proposed research. It is required that the Research Strategy be identical across linked collaborative U01 applications, with the exception of a short section describing specific function of each application under "elements unique to that site." For a linked set of collaborative U01 applications, each application must have its own Program Directory/Principal Investigator (PD/PI) and the program must provide a mechanism for cross-site coordination, quality control, data and sample sharing among the BSM Network members as appropriate, database management, statistical analysis, and reporting.     


  • Letter of Intent Due Date(s): 30 days before the application due date
  • Application Due Date(s): February 24, 2015; October 23, 2015; June 24, 2016; February 24, 2017, by 5:00 PM local time of applicant organization.

PAR-15-022 Expiration Date February 25, 2017




Medical - Basic Science
Medical - Clinical Science

External Deadline

February 24, 2017