LOI Deadline
Posted: 7/11/2024

Broad Pragmatic Studies Funding Announcement -- 2024 Standing PFA

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on May 7, 2024, which seeks to fund applications for high-quality patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement is provided to allow potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality proposals.

All applications must align the proposed research with at least one of the National Priorities for Health described within the PFA (Increase Evidence for Existing Interventions and Emerging Innovations in Health; Accelerate Progress Toward an Integrated Learning Health System; Achieve Health Equity; or Advance the Science of Dissemination, Implementation and Health Communication). Topic Themes are also included in this funding opportunity. Applicants have the option to choose up to three Topic Themes based on how their proposed research aligns with the themes. However, aligning with a Topic Theme is not required. The National Priorities for Health and Topic Themes will assist PCORI in determining the optimal review pathway for the proposed research.

Letter of Intent Deadline:

Cycle 1: February 6, 2024
Cycle 2: June 4, 2024
Cycle 3: Oct. 1, 2024

Areas of Interest

PCORI Topic Themes of interest that inform PCORI’s funding opportunities over the next several cycles. PCORI’s Topic Themes speak to everyday health issues facing large numbers of people in the United States including children, youth, and older adults and address urgent topics such as substance use, mental and behavioral health, violence and trauma, as well as widespread conditions including cardiovascular disease, pain management, and sleep health. These themes include four key topics that have been important interest areas for PCORI—preventing maternal morbidity and mortality, improving outcomes for people with intellectual and developmental disabilities (IDD), addressing COVID-19, and addressing rare disease. 

Applicants to the Cycle 2 2024 BPS PFA may select up to three of PCORI’s Topic Themes that best align with their proposed research. Applicants may also opt not to select from the PCORI Topic Themes and select “other” to indicate that their research aligns with other areas of important need for patient-centered CER. In keeping with past cycles, the BPS PFA welcomes all investigator-initiated, patient-centered CER.