Broad Pragmatic Studies Funding Announcement -- 2024 Standing PFA

Funding Agency:
Patient-Centered Outcomes Research Institute

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on January 9, 2024, which seeks to fund applications for high-quality patient-centered comparative clinical effectiveness research (CER) projects.

All applications must align the proposed research with at least one of the four National Priorities for Health described within the PFA. Topic Themes are also included in this funding opportunity. Applicants have the option to choose up to three Topic Themes based on how their proposed research aligns with the themes. However, aligning with any Topic Theme is not required. The National Priorities for Health and Topic Themes will assist PCORI in determining the optimal review pathway for the proposed research.

Letter of Intent Deadline:

Cycle 1: February 6, 2024
Cycle 2: June 4, 2024
Cycle 3: Oct. 1, 2024

Agency Website

Areas of Interest

PCORI has 12 Topic Themes of interest that inform PCORI’s funding opportunities over the next several cycles.  PCORI’s Topic Themes speak to everyday health issues facing large numbers of people in the United States including children, youth, and older adults and address urgent topics such as substance use, mental and behavioral health, violence and trauma, as well as widespread conditions including cardiovascular disease, pain management, and sleep health. These themes include four key topics that have been important interest areas for PCORI—preventing maternal morbidity and mortality, improving outcomes for people with intellectual and developmental disabilities (IDD), addressing COVID-19, and addressing rare disease. 

Applicants to the Cycle 3 2023 BPS PFA may select up to three of PCORI’s twelve Topic Themes that best align with their proposed research.  Applicants may also opt not to select from the PCORI Topic Themes and select “other” to indicate that their research aligns with other areas of important need for CER. In keeping with past cycles, the BPS PFA welcomes all investigator-initiated CER.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

February 6, 2024