Cancer Immune Monitoring and Analysis Centers (CIMACs) (U24) -- Deadline Extended

Funding Agency:
National Institutes of Health

This National Cancer Institute (NCI) funding opportunity announcement (FOA) solicits applications for multidisciplinary Cancer Immune Monitoring and Analysis Centers (CIMACs) that will serve as the main units of the Network for correlative studies in clinical trials involving immunotherapy. The Network will encompass two to three CIMACs (to be supported by this FOA) and a single Cancer Immunologic Data Commons (CIDC) (to be supported by the companion FOA, RFA-CA-17-006) forming a CIMACs-CIDC Network.

The Network is established to address the critical importance of biomarkers in management of cancer patients receiving immunotherapy. Specifically, each CIMAC will encompass a multidisciplinary group with basic, translational, clinical, and computational research expertise. CIMACs are expected to provide a wide range of state-of-the-art analyses for genomic, phenotypic and functional characterization of responses of patients in the NCI-sponsored early phase clinical trials using analytically-validated and standardized platforms. The Network activities will be facilitated by the CIDC in the following main areas: optimization of data collection methodologies suitable for immune-related biomarkers, data integration and building a biomarker database for the secondary use by the large immuno-oncology community.

The long term goal of the CIMACs-CIDC Network is to develop molecular signatures that define immune response categories to correlate with the clinical outcomes of immunotherapy in cancer. Collectively, the outcome of the Network research should lead to the identification of biomarkers with a translational potential for optimizing the therapeutic strategies for patients.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): New Date: March 17, 2017

RFA-CA-17-005 Expiration Date New Date March 18, 2017 per issuance of NOT-CA-17-019. (Original Expiration Date: March 4, 2017)

Agency Website



Amount Description

Each CIMAC application budget is limited to no more than $1.4M in direct costs for any budget year.

The total project period for an application submitted in response to this FOA may not exceed 5 years. 

Funding Type





Medical - Basic Science
Medical - Clinical Science

External Deadline

March 17, 2017