Sponsor Deadline
Posted: 4/21/2023

Cancer Prevention, Detection, Diagnosis, and Treatment Technologies for Global Health (U01 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) supports the development of cancer-relevant technologies suitable for use in low- and middle-income countries (LMICs). Specifically, the NOFO solicits applications for projects to adapt, apply, and validate existing or emerging technologies into a new generation of user-friendly, low-cost technologies for preventing, detecting, diagnosing, and/or treating cancers in people living in LMICs.

Applicants should have a working assay or device prototype (not necessarily already capable of cancer applications). The U01 project includes studies to both adapt this technology as well as demonstrate technical functionality and clinical performance for use of the device or assay in specific LMIC settings by meeting objective performance milestones followed by improvements and validations of the technologies in the LMIC settings. Projects proposed in response to this NOFO will require multidisciplinary efforts to succeed; therefore, all applicant teams must include expertise in engineering/assay/treatment development, oncology, global healthcare delivery, and business development. Investigators responding to this NOFO must consider affordability and cost-effectiveness as well as usability at the point-of-need as part of their design criteria.

This NOFO is part of a broader NCI-sponsored Affordable Cancer Technologies (ACTs) Program.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date(s): October 13, 2023

RFA-CA-24-005 Expiration Date October 14, 2023

Eligibility Requirements

Individuals from both the high-income countries (HIC), such as the U.S., and the LMIC institutions are eligible PDs/PIs. The main collaborating individual(s) from the proposed HIC and LMIC institutions must serve as PDs/PIs or other key personnel. Multi-PI applications are encouraged.

Amount Description

Applicants may request up to $475,000 in direct costs per year.

The proposed project period must not exceed 5 years.