This Funding Opportunity Announcement (FOA) invites a single cooperative agreement application for a data coordinating center that first establishes a biorepository of human cardiovascular (CV) tissue and then serves as a coordinating center resource for discovery and mechanistic research to increase our knowledge of the CV complications of type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of death and morbidity for individuals with T1D, but no T1D-specific therapy exists to prevent or treat this complication of diabetes because of challenges from inadequate preclinical models, decades-long disease progression and poorly defined differences in pathogenesis compared to type 2 diabetes (T2D). The FOA will support a two-phase research plan to encourage the use of human CV tissue to overcome these challenges. The goal of the first phase is to establish a biorepository through 1) the collection and storage of human cadaveric tissues from donors with T1D, T2D, and without diabetes; 2) the performance of quality control and basic histopathologic examination; and 3) the creation of a process for distribution of the biosamples and data to qualified investigators. The goal of the second phase is to serve as a coordinating center resource for investigators seeking to perform a multimodal analysis to deeply phenotype the anatomical, cellular, and molecular composition of the tissues and make the results available in a public data portal.
Only one application per institution is allowed.
Deadlines:
- Duke Internal: TBA
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Letter of Intent Due Date(s): September 20, 2021
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Application Due Date: October 20, 2021
RFA-DK-21-010 Expiration Date October 21, 2021
The PD/PI must have experience with obtaining post-mortem tissue for research purposes from Organ Procurement Organizations.
Application budgets are limited to directs costs of $1 million for each year in years 1 and 2 and $1.3 million for each year in years 3-5 and should reflect the actual needs of the proposed project.