Sponsor Deadline
Posted: 4/18/2022

Cardiovascular Biorepository for Type 1 Diabetes (U24 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites a single cooperative agreement application for a data coordinating center that first establishes a biorepository of human cardiovascular (CV) tissue and then serves as a coordinating center resource for discovery and mechanistic research to increase our knowledge of the CV complications of type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of death and morbidity for individuals with T1D, but no T1D-specific therapy exists to prevent or treat this complication of diabetes because of challenges from inadequate preclinical models, decades-long disease progression and poorly defined differences in pathogenesis compared to type 2 diabetes (T2D). The FOA will support a two-phase research plan to encourage the use of human CV tissue to overcome these challenges. The goal of the first phase is to establish a biorepository through 1) the collection and storage of human cadaveric tissues from donors with T1D, T2D, and without diabetes; 2) the performance of quality control and basic histopathologic examination; and 3) the creation of a process for distribution of the biosamples and data to qualified investigators. The goal of the second phase is to serve as a coordinating center resource for investigators seeking to perform a multimodal analysis to deeply phenotype the anatomical, cellular, and molecular composition of the tissues and make the results available in a public data portal.

Only one application per institution is allowed.


  • Duke Internal: TBA
  • Letter of Intent Due Date(s): September 20, 2021

  • Application Due Date: October 20, 2021

RFA-DK-21-010 Expiration Date October 21, 2021

Areas of Interest



Eligibility Requirements

The PD/PI must have experience with obtaining post-mortem tissue for research purposes from Organ Procurement Organizations.

Amount Description

Application budgets are limited to directs costs of $1 million for each year in years 1 and 2 and $1.3 million for each year in years 3-5 and should reflect the actual needs of the proposed project.

Funding Type