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Cellular Senescence Network: Tissue Mapping Centers (U54 - Clinical Trial Not Allowed
The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) to work within the Cellular Senescence Network (SenNet). The goal of the SenNet consortium is to identify and functionally characterize the heterogeneity of senescent cells across multiple tissues in human health, disease, and lifespan at single-cell resolution. Through collaborative efforts, the consortium will generate a multimodal, multidimensional Atlas of senescent cells in various human tissues; develop innovative tools and technologies to identify and characterize senescent cells; and aggregate data across the Network into a searchable Atlas of Cellular Senescence, ensure the utility of the database, and promote collaboration through Network engagement with the research community. The TMCs solicited through this RFA will generate the high-resolution, high-content, multiscale biomarkers and maps of cellular senescence across the lifespan and physiological states necessary to generate the Senescence Atlas. The SenNet is focused on healthy human tissues, and work in diseased tissue or animal models is acceptable only as long as it is used to support this overall goal. TMCs will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through analyses at organ, tissue and single cell level using omics, imaging and other approaches, to data integration, analysis and interpretation.
Letter of Intent Due Date(s): New Date February 22, 2021
Application Due Date(s): New Date March 22, 2021
RFA-RM-21-008 Expiration Date New Date March 23, 2021 per issuance of NOT-RM-21-011. (Original Expiration Date: March 9, 2021)
An investigator designated as the Contact PD/PI or MPI of an application under this FOA must not be the designated Contact PD/PI of another application under the companion SenNet FOAs RFA-RM-21-009 and RFA-RM-21-010.