Sponsor Deadline
Posted: 3/14/2024

Center of Excellence for Systems Modeling of Infection and Immunity across Biological Scales (U54 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to support the establishment of one (1) Center of Excellence (CoE) to coordinate the research community of infectious and immune-mediated disease (IID) computational modelers and advance IID modeling research across biological scales. The CoE must include three (3) Coordinating Cores and two (2) Research Projects to advance and integrate bridge models across scales in the context of IID, including HIV/AIDS. The CoE will accelerate multi-scale model development, sharing and re-use, and support collaboration to benefit the entire IID research community.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation.  Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date: June 4, 2024

RFA-AI-23-077 Expiration Date June 05, 2024


Amount Description

Application budgets are not expected to exceed $3.125 million in direct costs per year, which includes an expectation that the budget for the Opportunity Fund will not exceed $0.3 million in direct costs per year. Application budgets need to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.