Center without Walls for the Identification and Validation of Molecular Mechanisms Contributing to Tau Pathogenesis and Associated Neurodegeneration in Frontotemporal Degeneration (FTD) (U54)

Funding Agency:
National Institutes of Health

The purpose of this FOA is to support innovative interdisciplinary, multi-institute research that will lead to the identification and validation of molecular mechanisms relevant to human biology that contribute to tau toxicity associated with Frontotemporal Degeneration (FTD). It is anticipated that this research will also contribute to tool development that can be applied to target validation in FTD clinical trials.  Applications must include an administrative core, a scientific governance structure, a minimum of three research projects with milestone plans, resource core(s) that support the basic research efforts of at least two proposed research projects, a data coordination core that will facilitate the distribution of data generated through the Center without Walls with the broad research community and a human biology validation core that will support the validation of mechanisms identified and resources developed under this FOA. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. This FOA is in response to the Alzheimer's Disease Related Dementias (ADRD) challenges outlined in the 2015 update to the National Plan to Address Alzheimer's Disease.

This FOA does not support clinical trials or projects focused predominantly on translational research activities.  


  • Letter of Intent Due Date(s): April 10, 2016
  • Application Due Date(s): May 10, 2016, by 5:00 PM local time of applicant organization.

​RFA-NS-16-023 Expiration Date May 11, 2016

Agency Website

Eligibility Requirements

The Center without Walls Director (PD/PI) should be an established leader in scientific research with a history of successful funding and proven expertise in the stewardship of large-scale research programs. Center Directors must lead a Project and/or Core within the Center. Other qualifying factors include current research productivity, active funding (NIH R01-equivalent or greater) and the capacity for visionary leadership of an interdisciplinary team. Expertise in areas beyond tau biology is encouraged if the Director’s skills can be applied in novel ways that will stimulate new approaches and the application of new technologies for interrogating the underlying mechanisms of tau toxicity as they relate to FTD.



Amount Description

Application budgets are limited to $1,500,000 in direct costs per year and budgets need to reflect the actual needs of the proposed project.

The maximum project period is 5 years. 

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

May 10, 2016