This Notice of Funding Opportunity (NOFO) invites new applications for Centers for Collaborative Research in Fragile X and FMR1-Associated Conditions (hereafter termed "Fragile X Centers").
Despite many remarkable advances in fundamental knowledge about FMR1-associated conditions, there remains a need to: (1) identify, characterize, and/or model factors that predict subgroup- or individual-level differences in clinical features (“phenotypic heterogeneity”) and/or responses to specific interventions among affected individuals; (2) identify novel mechanisms and targets for intervention that modulate symptom severity or therapeutic efficacy; and (3) identify and validate translatable biomarkers and/or outcome measures for potential use in clinical trials. All centers will be required to identify an overarching theme directed at broadening our understanding of one of these three research priority areas in FMR1-associated conditions.
Successful Fragile X Centers will be composed of multidisciplinary teams of basic, translational, clinical, and/or data science investigators collaborating to address complex, difficult-to-solve problems within specific research priorities identified in the NIH FMR1 Strategic Plan.
This NOFO includes specific requirements about inclusion of research on human subjects or human phenotypic data; diversity of participants; sources of materials being studied; and the types of allowable clinical trials. Applications that do not adhere to these requirements will be considered nonresponsive to this NOFO and will be withdrawn.
This Notice of Funding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).
Deadlines:
- Letter of Intent Due Date(s): July 06, 2024
- Application Due Date: August 20, 2024
RFA-HD-25-002 Expiration Date New Date August 20, 2024 (Original Date: August 07, 2024) per issuance of NOT-HD-24-026
No individual may serve as key personnel on more than one application submitted to this funding opportunity.
Applications may request up to $1.2 million in direct costs per year (excluding subaward F & A costs) and need to reflect the actual needs of the proposed project.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.