Childhood Asthma in Urban Settings Clinical Research Network- Leadership Center (UM1 Clinical Trial Required)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the NIAID Childhood Asthma in Urban Settings Clinical Research Network Leadership Center (CAUSE-LC). The CAUSE-LC will provide the overall scientific strategy and organizational structure to the CAUSE Clinical Research Network and will interact closely with the CAUSE Clinical Research Centers (CAUSE -CRCs) to support the conduct of multi-site clinical studies and trials with the ultimate goal of developing effective interventions or asthma prevention approaches applicable to children residing in low-income urban settings.


Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed.


  • Duke Internal: Mar. 20, 2020
  • Letter of Intent: 30 days prior to the application due date
  • Application: June 19, 2020

RFA-AI-19-074 Expiration Date: June 20, 2020

Agency Website

Eligibility Requirements

Applicants may submit to both the CAUSE-LC (RFA-AI-19-074) and CAUSE-CRC (RFA-AI-19-073) funding opportunities. However, different clinical projects must be proposed in each of the two applications.

Amount Description

Application budgets are limited to $4.3 million direct costs and need to reflect the actual needs of the proposed projects. This includes funding for 1) the CAUSE-LC functions, 2) the CAUSE network-wide clinical projects including protocol-specific funds for the CAUSE-CRCs and for the mechanistic studies incorporated in these projects, 3) the final 3 (possibly 4) years of the URECA birth cohort.
The proposed project period must be 7 years.

      Funding Type





      Environmental & Life Sciences
      Medical - Clinical Science
      Medical - Translational

      Internal Nomination

      Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

      • NIH Biosketch of PI
      • Specific Aims (1 page)
      • List names of individuals/organizations from which letters of support will be requested (see Letter(s) of Support under Section IV of the solicitation for details)

      Please submit internal materials through My Research Proposal. (Code ILN)

      Instructions for both creating an account (if you don't already have one) and submitting your materials can be found here:

      Internal Deadline

      March 20, 2020

      External Deadline

      June 19, 2020