Clinical Centers for the NHLBI's Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE) Network (UG1) -- Deadline Extended

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) invites applications to participate in the NHLBI Precision Interventions for Severe and Exacerbation Prone Asthma (PrecISE) Network. This clinical trial network will conduct sequential, adaptive, phase II/proof of concept clinical trials with precision interventions in stratified patient populations. The Network will utilize patient phenotypes and/or endotypes, predictive, and monitoring biomarkers/profiles in sequential adaptive trials to evaluate the most effective precision intervention strategies for this hard to treat patient population.  PrecISE will include multiple clinical centers and a single Data, Modeling, and Coordination Center (DMCC). This FOA invites applications for the Clinical Centers (CC) and runs in parallel with a companion FOA that invites applications for the DMCC (RFA-HL-17-010).


  • Letter of Intent Due Date(s): New Date, November 28, 2016 per issuance of NOT-HL-16-459
  • Application Due Date(s): New Date, December 28, 2016

​RFA-HL-17-009 Expiration Date New Date, December 29, 2016 per issuance of NOT-HL-16-459. (Original Expiration Date: December 21, 2016)

Agency Website

Eligibility Requirements

The Project Director/Principal Investigator (PD/PI) or contact PD/PI should have strong expertise in adult and pediatric asthma (children >11 years of age).

Amount Description

Application budgets are limited to $210,000 direct costs in Fiscal Year 2017, $275,000 direct costs in Fiscal Years 2018 through Fiscal Year 2021, and $250,000 in Fiscal Year 2022 to support research infrastructure. Protocol budgets should be commensurate with the scope and complexity of the protocol.

The scope of the proposed project should determine the project period. The maximum project period is up to 6 years.

Funding Type





Engineering and Physical Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

December 28, 2016