Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R03, R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling efficient and effective movement of candidate therapeutics or diagnostics toward clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.

Although this funding opportunity uses the R03 grant mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-23-159, which uses the R21 grant mechanism.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s):   May 15, 2023; Oct 17, 2023; May 13, 2024; Oct 17, 2024

​PAR-23-160 Expiration Date October 18, 2024




Medical - Clinical Science
Medical - Translational

External Deadline

May 13, 2024