"Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This FOA invites applications for projects designed to test the effectiveness of microphysiological systems (MPS), also called “tissue chip,” technology, for clinical trial frameworks by demonstrating their applied use in clinical trial planning and execution, addressing both safety and efficacy in late-stage preclinical studies. This approach is to provide evidence of the utility of tissue chip technology for precision medicine in informing trial design, establishing recruitment criteria and stratification of patient populations in identifying the best responders to candidate therapeutics.   


  • Letter of Intent Due Date(s): September 9, 2019
  • Application Due Date(s): October 9, 2019

RFA-TR-19-014 Expiration Date October 10, 2019

Agency Website

Amount Description

Budget requests are limited to $500,000 direct cost per year.

The scope of the proposed project should determine the project period. The maximum project period is 5 years limited to up to 2 years for the UG3 phase, and up to 3 years for the UH3 phase.


      Funding Type





      Engineering and Physical Sciences
      Environmental & Life Sciences
      Medical - Basic Science
      Medical - Clinical Science
      Medical - Translational

      External Deadline

      October 9, 2019