Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) program is designed to support integrated efforts of three to six PDs/PIs to pursue a bold, impactful, and challenging goal with defined 5-year outcomes within the scope of this program and the NINDS mission. This defined research goal must only be achievable by an interdisciplinary team approach involving innovative combination of distinct disciplines and/or intellectual viewpoints, synergy in expertise and approaches, and well-managed team interactions. Proposed research must not represent a collection of individual efforts or parallel projects, but rather an integrated effort from all PIs to achieve a single, transformative research goal. This program is distinct from the NINDS P01 and parent R01 in that it will support a single, focused goal instead of multiple aims.


  • Letters of Intent Due Date(s):  At least 30 days before the application due date.
  • Application Due Dates(s): Oct 20, 2023; Oct 8, 2024

RFA-NS-23-027 Expiration Date: October 09, 2024

Agency Website

Eligibility Requirements

The application is required to be submitted as a multiple PD/PI application, with 3-6 PDs/PIs. We require equivalent efforts from 3-6 investigators with Principal Investigator roles as each PI is expected to provide a significant, indispensable, and distinct contribution to the project. Teams should not be dominated by a single individual. Multiple PDs/PIs on a project share the authority and responsibility for leading and directing the project, intellectually and logistically. Generally, each PD/PI should devote at least 2.4 person months (i.e., the equivalent of 20% effort on a full-year appointment, 26.7% on a 9-month appointment, or 40% on a 6-month appointment) throughout the duration of the award. Visit the multiple PD/PI Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide, and the Grant Policy Statement on Multiple Principal Investigators. Minimum allowed efforts by the PDs/PIs are described in the R&R Budget instructions in Part 2. Section IV.2.

PD(s)/PI(s) who have an active NINDS R35 award can participate as a Collaborator instead of a PD/PI as part of the 50% effort on their current R35 award and may not receive additional funds from this award. 

Multiple PD/PI projects will be subject to the NINDS Special Review Council (SCR) policy if one or more of the PD/PIs has NIH research support that exceeds the SCR threshold.

    Amount Description

    Application budgets need to reflect the actual needs of the proposed project. It is anticipated that most awards will be between $500,000-$1.5M direct costs.

    Funding Type





    Engineering and Physical Sciences
    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    October 20, 2023