Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures

Funding Agency:
Patient-Centered Outcomes Research Institute

The Patient-Centered Outcomes Research Institute (PCORI) intends to reissue a Targeted PCORI Funding Announcement on September 7, 2022, seeking to fund high-quality, comparative clinical effectiveness research (CER) projects that focus on multimodal interventions to prevent fractures in people with osteoporosis and a history of a fracture. This preannouncement is provided to allow potential applicants additional time to identify collaborators; obtain stakeholder input on potential studies; and develop responsive, high-quality proposals.

Fracture is a significant consequence from osteoporosis with estimates of one in two women and up to one in four men experiencing a fracture in their lifetime due to osteoporosis, which translates to about 2 million people affected annually. Consequences of osteoporotic-related fractures include significant mortality and morbidity, with decreases in functional independence, quality of life, and ability to live in the community. Another consequence of fracture is a subsequent fracture, with about 10 percent refracturing within 1 year and 30 percent within 5 years.

Osteoporosis treatment is multimodal and includes drug therapies and nonpharmacological interventions. While evidence exists for single interventions, broad evidence gaps exist around multimodal interventions to prevent second fractures and stakeholders have identified more research as a priority.

Letter of Intent Deadline: Oct. 4, 2022




Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

October 4, 2022