Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)

Funding Agency:
National Institutes of Health


The National Institutes of Health (NIH) hereby notifies NIH award recipients that funds may be available for revision applications to support the expansion of existing projects and/or programs within the awarding Institute or Center (IC) identified in the competitive revision Notice of Special Interest (NOSI).

Only applications submitted in response to a NOSI published by an NIH Institute or Center will be allowed to apply to this NOFO.   

See the competitive revision NOSI for any applicable Application Due Dates.

PA-23-317 Expiration Date November 24, 2026

Agency Website

Eligibility Requirements

All organizations administering an eligible parent award may apply for a competitive revision under this opportunity unless otherwise stated in the terms and conditions of the parent award.

Individual(s) must be designated as a PD/PI on an active grant or cooperative agreement award, and the research proposed in the competitive revision must be accomplished within the competitive segment of the active award. Individuals are encouraged to work with their organizations to develop applications for support.

For competitive revisions to parent awards that include multiple PDs/PIs, the competitive revision may be requested by any or all of the PDs/PIs (in accordance with the existing leadership plan) and submitted by the recipient organization of the parent award. Do not use this competitive revision application to add, delete, or change the PDs/PIs listed on the parent award. Visit the Multiple Program Director/Principal Investigator Policy in the SF424 (R&R) Application Guide for more information.

Amount Description

Specific budget limits may be specified in the competitive revision NOSI. Application budgets must be reasonable and must reflect the actual needs of the proposed project.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

November 24, 2026