Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R41/R42, R43/R44)

Funding Agency:
National Institutes of Health

The overarching goal of the STTR program at the National Institute of Mental Health (NIMH) is to support small businesses to develop technologies that can advance the mission of the Institute, including in basic neuroscience research relevant to mental disorders, translational and clinical research of mental disorders, clinical diagnosis or treatment of mental disorders, and dissemination of evidence-based mental health care.  This FOA encourages STTR grant applications to support research and development of particular priority research topics - complex technologies that require funding levels and durations beyond those reflected in the standard STTR guidelines. 

Companion FOA: PA-18-566 Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track


  • Letter of Intent: 30 days prior to the application due date
  • Application Due Date(s): Sep. 5, Jan. 5, Apr. 5

PA-18-579 Expiration Date: New Date April 6, 2021 per issuance of NOT-MH-21-135. (Original Expiration Date: January 6, 2021)

Agency Website

Eligibility Requirements

Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. 

Amount Description

Budgets of up to total $450,000 per year total cost for Phase I awards and $750,000 per year total cost for Phase II awards, and $1,000,000 per year total cost for Phase IIB may be requested.  

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

April 5, 2021