Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This funding opportunity seeks to support the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) Program. The CPACHE Program develops and maintains comprehensive, long-term, and mutually beneficial partnerships between institutions serving underserved health disparity  populations and underrepresented students (ISUPSs) and NCI-designated Cancer Centers (CCs). The program aims to achieve a stronger national cancer program and address challenges in cancer and cancer disparities research, education, and outreach, as well as cancer's impact on underserved populations.

The institutions in each partnership are expected to work collaboratively to: 1) increase the cancer research and cancer research education capacity of the ISUPSs; 2) promote the diversity of the cancer research workforce; 3) improve the effectiveness of CCs in developing and sustaining research programs focused on cancer health disparities and increase the number of investigators and students conducting cancer health disparities research; and 4) develop and implement cancer-related outreach and education initiatives that benefit the surrounding underserved communities.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date: January 16, 2024; Oct. 9, 2024; Oct. 9, 2025

PAR-23-308 Expiration Date October 10, 2025 per issuance of NOT-CA-24-011 (Original Expiration Date: January 17, 2024 )

Agency Website

Eligibility Requirements

Each partnership must include both types of institutions: 1) ISUPS , and 2) NCI-designated Cancer Center  (CC ). Partnerships involving more than two institutions require NCI approval before applying.

ISUPSs with medical schools or with more focused education and research programs (e.g., Masters and PhD programs), as well as those that offer only Baccalaureate degrees and Tribal Colleges, may all participate in this initiative. 

For this funding opportunity announcement, ISUPS are defined as institutions with a documented historical and current mission to serve underserved health disparity  populations and underrepresented students.

In spite of tremendous advancements in scientific research, information, educational and research opportunities are not equally available to all. NIH encourages institutions to diversify their student and faculty populations to enhance the participation of individuals from groups that are underrepresented in the biomedical, clinical, behavioral and social sciences. For additional detail refer to 

  • Although grants are awarded to institutions, not investigators, the PD(s)/PI(s) are preferred to be mid-to-senior-level scientists who have records of obtaining grant support and will serve as role models and mentors to the partnership participants. However, a less-experienced investigator at an ISUPS can be designated as one of multiple PDs/PIs if there is an appropriate institutional investment in this investigator and a demonstrable collaboration (active or planned) of the less-experienced investigator with a more-experienced PD/PI.
  • To underscore their commitment to the partnership, contact PDs/PIs should also be reciprocally listed as PD(s)/PI(s) on the linked application from the partnering institution.

Please note that specifically for this NOFO, the NCI will support only one U54 partnership for each institution.

Amount Description

Application budgets are limited to $1.7 million in direct costs per year for partnerships of two institutions and $2.2 million in direct costs per year for partnerships of three institutions.

Funding Type





Community Outreach and Engagement
Curriculum Development
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

October 9, 2024