Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) solicits applications for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct versus overlapping neural circuits? What are the relationships between domains, constructs and subordinate sub-constructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposed research projects will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illnesses.


  • Letter of Intent Due Date(s): December 3, 2018; October 20, 2019; October 20, 2020
  • Application Due Date(s): January 3, 2019; November 20, 2019; November 20, 2020

RFA-MH-19-242 Expiration Date November 21, 2020

Agency Website



Amount Description

Application budgets may not exceed $1,000,000 direct costs annually, including any consortium F&A, and are expected to reflect actual needs of the proposed project
The total project period for an application submitted in response to this FOA may not exceed five years. 

Funding Type





Engineering and Physical Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

November 20, 2020