This Notice of Funding Opportunity (NOFO) solicits applications for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria (RDoC) matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This NOFO seeks research that addresses the following questions: Do the different domains of behavior segregate from each other? How much do they rely on distinct versus overlapping neural circuits? What are the relationships between domains, constructs, and subordinate sub-constructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposed research projects ?will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This NOFO seeks to promote projects where the computational and the experimental components are well integrated. To ensure ecological validity of these studies, models derived from lab-based behavioral tasks will need to be tested for generalizability to behavioral data collected in a real-world setting. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illnesses.

Companion FOA: PAR-23-305 Computationally-Defined Behaviors in Psychiatry (R21 Clinical Trial Optional)

Deadlines:

• Letter of Intent Due Date(s):  October 1, 2023
• Application Due Date(s): Nov 1, 2023

PAR-23-307 Expiration Date November 02, 2023