The FY23 ARP Career Development Award supports early-career, independent investigators and/or the transition of established investigators from other research fields to conduct innovative,high-impact ideas or early-phase, proof-of-principle clinical trials with the potential to have a major impact on ASD. Applications are strongly encouraged to address one of the FY23 ARP Career Development Award Areas of Interest or provide justification that the proposed research addresses a critical problem, question, or need in ASD.
This award enables such investigators to compete for funding separately from investigators with established programs of ASD research. Previous experience in ASD research is allowed, but not required. However, in FY23 Career Development Award applications that name a Principal Investigator (PI) with limited background in ASD research, the ARP strongly encourages the inclusion of collaboration with investigators who are experienced in ASD research and/or possess other relevant expertise in order to strengthen the application. PIs must meet specific eligibility criteria as described in Section II.C, Eligibility Information.
Research funded by the FY23 ARP should be responsive to the needs of people with ASD, their families, and/or caregivers. Researchers are therefore encouraged to establish and utilize effective collaborations and partnerships with community members to maximize the translational and impact potential of the proposed research.
Deadlines:
• Required Pre-Application Deadline: April 19, 2023
• Invitation to Submit an Application: May 2023
• Application Submission Deadline: July 20, 2023
The FY23 ARP Career Development Award seeks applications from all areas of research. However, if the proposed research project does not address at least one of the FY23 ARP Career Development Award Areas of Interest, justification should be provided that the proposed research addresses a critical problem, question, or need in ASD.
The ARP encourages applications that address critical needs of the ASD community in one or more of the FY23 ARP Career Development Award Areas of Interest: • Assessment of novel therapeutics using valid preclinical models • Create tools and strategies to increase the speed with which evidence-based practices are deployed in community-based settings • Cultural, socioeconomic, and gender factors in diagnosis, treatment efficacy, delivery, and access to services • Development of healthcare provider-focused training or tools to improve healthcare delivery for autistic individuals across the life span and the continuum of care (i.e., primary care, urgent/emergent care, and disaster relief) • Environmental risk factors • Factors impacting quality of life during geographic relocation, such as military permanent change of station • Factors promoting success in key transitions to independence for individuals living with ASD • Improve diagnosis and access to services across the life span • Interventions to support ASD adults, including transition to adulthood, mid-life, and late life needs • Long-term treatment outcomes from previous clinical trials for ASD core symptoms or to alleviate co-occurring conditions • Mechanisms of heterogeneous clinical expression of ASD • Mechanisms underlying sex differences (i.e., prevalence, biological mechanisms, phenotypic expression, core and comorbid syndrome expression and outcomes, developmental trajectories, diagnosis, and treatment response) • Mechanisms underlying conditions co-occurring with ASD (e.g., sleep disturbances, gastrointestinal issues, inflammation, aggression, depression, anxiety, attention deficit, and seizures) • (New for FY23) Mental health issues (such as grief, masking, suicide risk, trauma, etc.) or disorders in autistic individuals • Tests of implementation strategies to increase use of evidence-based practices • (New for FY23) Understanding heterogeneity in treatment response, including identification of psychosocial or biological factors that (1) impact treatment outcomes or (2) can be used to prospectively identify treatments that are most likely to benefit particular subgroups of individuals. • Understanding key factors to support ASD adults, including transition to adulthood • (New for FY23) Understanding physical health and related issues in aging autistic adults including cardiovascular issues, joint pain, asthma, obesity, etc.
The investigator named by the organization as the PI on the application may select one of the following eligibility categories. These eligibility criteria pertain as of the application submission deadline:
○ An independent investigator at or below the level of Assistant Professor, Instructor, or equivalent; or
○ An established independent investigator in an area other than ASD at or above the level of Assistant Professor seeking to transition to a career in ASD thereby bringing their expertise to the field.
In addition, the PI must:
○ Not have received a Career Development Award (or equivalent) previously from any program within the CDMRP.
○ Not have received more than $300,000 in total direct costs for previous or concurrent ASD research as a PI of one or more federally or privately funded, non-mentored, peerreviewed grants.
○ Must hold a Ph.D., M.D., M.D./Ph.D., or equivalent at time of pre-application submission.
○ Not be a graduate student, postdoctoral fellow, or other “mentored” researcher.
The anticipated direct costs budgeted for the entire period of performance for an FY23 ARP Career Development Award should not exceed $550,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
