Congressionally Directed Medical Research Programs (CDMRP) -- Epilepsy Research Program -- Epilepsy Risk Factors Award

Funding Agency:
Department of Defense

The Epilepsy Risk Factors Award (ERFA) is being offered for the first time in FY17. 

The intent of the FY17 ERP ERFA is to conduct preliminary studies that may provide the framework to support large-scale, prospective, longitudinal epidemiological research relevant to the characterization of PTE. Study design should indicate how the research strategy can generate preliminary data capable of supporting larger, more complex studies. The proposed study design may be either prospective or retrospective. Applications should describe how the association of TBI and subsequent PTE will be characterized. Studies that evaluate the feasibility of using combinations of measures (e.g., neuropsychological assessments, imaging, and genomics) are encouraged. Due to the intent of this mechanism, preliminary data are not required. As part of the application process, all applicants are required to provide an Epidemiological Research Statement.


  • REQUIRED Pre-application Submission Deadline:  September 21, 2017 (was September 6, 2017)
  • Full Application Submission Deadline:  October 5, 2017 (was September 20, 2017)

Agency Website

Areas of Interest

​FY17 ERP ERFA Focus Areas: The research impact for the FY17 ERP ERFA will benefit the military, Veteran, and civilian communities. To this end, applications should address at least one of the following FY17 ERP ERFA Focus Areas. An application that proposes research outside of these FY17 ERP ERFA Focus Areas is acceptable, as long as the applicant provides a strong rationale. These should be carefully considered as part of the application process.

 Epidemiology: Epidemiological characterization of PTE following TBI, which may include: ○ Risk factors such as demographics, genetic factors, organic head injury factors, or type of insult ○ Differentiation of PTE and psychogenic non-epileptic seizures (PNES) ○ Outcomes including latency to epilepsy, morbidities and comorbidities, and mortality ○ Pre-existing conditions including psychological and psychiatric risk factors

Markers and Mechanisms: Identifying markers or mechanisms (via clinical prospective or preclinical models) that address PTE: ○ Early detection ○ Diagnosis ○ Prognosis ○ Morbidity ○ Comorbidity ○ Mortality ○ Risk stratification

Eligibility Requirements

To be considered for an FY17 ERP ERFA, the Principal Investigator (PI) must be an independent investigator at or above the level of Assistant Professor (or equivalent). Each investigator may submit only one FY17 ERP ERFA application as a PI.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY17 ERFA will not exceed $300,000. The maximum period of performance is 2 years. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

September 21, 2017