Applications to the FY23 ERP Leveraging Research Award (LRA) should address at least one of the Focus Areas listed below. Applications may address more than one Focus Area. An application that proposes research outside of these FY23 ERP Focus Areas is also acceptable, as long as the applicant provides a strong justification as to why the topic is critical to advance understanding of PTE and addresses the ERP mission.
• Markers and Mechanisms: Identifying biomarkers or mechanisms of PTE, which may include the following: ○ Predictive biomarkers of epileptogenesis (acute and chronic) ○ Research into the prevention of epilepsy and/or seizures
• Epidemiology: Epidemiological characterization of PTE following TBI, which may include the following: ○ Understanding and improving the quality of life of individuals with PTE, their families, and/or their care partners ○ Predictors of the development of epilepsy ○ Outcomes, including latency to and prevention of epilepsy, comorbidities, and mortality
• Longitudinal Studies: Studies of the evolution of PTE, which may include the following: ○ Understanding and improving the quality of life of individuals with PTE, their families, and/or their care partners ○ Treatment and healthcare outcomes research, including quality of care ○ Natural history of PTE and prognosis ○ Comorbidities (e.g., depression, functional deficits, sleep disorders, major illness)
• Innovative Research: Tools intended to better inform or improve upon PTE research and care, which may include the following: ○ Strategies that will improve seizure detection, characterization, visualization, or diagnosis ○ Development of new models or better characterization of existing etiologically relevant models for PTE
The named Principal Investigator (PI) may be an investigator at any career level. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by or affiliated with an eligible organization.
The anticipated direct costs budgeted for the entire period of performance for an FY23 ERP LRA Award should not exceed $250,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.