The intent of the FY24 ERP RPA is to create an avenue to support new or existing collaborative research partnerships between/among investigators to address a research problem or question in a manner that would be unachievable through separate efforts. It is expected that investigators will utilize their distinct but complementary perspectives to synergistically address a central problem or question critical to PTE research and those living with PTE, their families, and/or their care partners.
Deadlines:
To meet the intent of the funding opportunity, applications to the FY24 ERP Research Partnership Award (RPA) should address at least one of the Focus Areas listed below. Applications may address more than one Focus Area. An application that proposes research outside of these FY24 ERP Focus Areas is also acceptable, as long as the applicant provides a strong justification as to why the topic is critical to advance understanding of PTE and how it addresses the ERP mission.
• Markers and Mechanisms: Identifying biomarkers or mechanisms of PTE, which may include the following:
○ Predictive biomarkers of epileptogenesis (acute and chronic)
○ Research into the prevention of epilepsy and/or seizures
• Epidemiology: Epidemiological characterization of PTE following TBI, which may include the following:
○ Understanding and improving the quality of life of individuals with PTE, their families, and/or their care partners
○ Predictors of the development of epilepsy
○ Outcomes, including latency to and prevention of epilepsy, comorbidities, and mortality
• Longitudinal Studies: Studies of the evolution of PTE, which may include the following:
○ Understanding and improving the quality of life of individuals with PTE, their families, and/or their care partners
○ Treatment and health care outcomes research, including quality of care
○ Comorbidities (e.g., psychiatric disorders, cognitive/physical deficits, sleep disorders, fatigue)
• Innovative Research: Tools intended to better inform or improve upon PTE research and care, which may include the following:
○ Strategies that will improve seizure detection, characterization, visualization, or diagnosis (e.g., artificial intelligence, bioinformatics, clinical databases, devices, tissue banks)
○ Development of new models or better characterization of existing etiologically relevant models for PTE
The Initiating PI and partnering PI(s) may be investigators at any career level. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by or affiliated with an eligible organization.
The anticipated direct costs budgeted for the entire period of performance for an FY24 ERP RPA should not exceed $1,200,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
