Congressionally Directed Medical Research Programs (CDMRP) -- Neurofibromatosis Research Program -- Research Academy-Leadership Award

Funding Agency:
Department of Defense

The NFRP Neurofibromatosis Research Academy (NFRA) will bring together established investigators (Director and Deputy Director) and early-career independent investigators (Scholars) to develop successful, highly productive neurofibromatosis researchers that will conduct research with the aim of lessening the clinical impact of NF1, NF2, and Schwannomatosis. The NFRA is a unique, multi-institutional interactive virtual research academy focused on supporting innovative high-impact research in a collaborative research and career development environment. The NFRA will provide a framework of intensive monitoring and iterative guidance with proposed research, national networking, collaborations, and a peer group for Scholars.

The NFRA is a platform that consists of Scholars and their Career Guides (mentors) from different institutions, and an Academy Director and Deputy Director (see Figure 1 below). The Academy Director and Deputy Director catalyze the growth and professional development of the Scholars in collaboration with their Career Guides, assess the progress of the Scholars, and facilitate communication and collaboration among all Academy members. The Career Guide is not required to be at the same institution as the Scholar; however, if the (primary) Career Guide is from a different institution, a secondary Career Guide at the Scholar’s institution is needed. The NFRA will give Scholars opportunities to operate in a collegial, highly dynamic, and cutting-edge center to lead neurofibromatosis research to a new frontier. The NFRA will provide a platform for Scholars to collaborate with leaders in the neurofibromatosis field and advance research for neurofibromatosis patients. The NFRA leadership team will also provide opportunities to NFRP FY23 (and subsequent year awardees) Early Investigator Research Award and NFRP FY23 (and subsequent year awardees) New Investigator Award - Early-Stage Investigator researchers to engage with NFRP NFRA Scholars.

This FY23 funding opportunity is soliciting applications for an Academy Director and Deputy Director to lead the NFRA. The Academy Director and Deputy Director (referred to as Academy Leadership) must be established neurofibromatosis researchers and can be at different institutions. The Academy Leadership must demonstrate a strong record of mentoring and training early-career independent investigators, a commitment to leadership, the ability to articulate methods toward research collaborations, and the ability to objectively assess the progress of all Scholars in the NFRA. Early-career independent investigators interested in applying to become a member of the NFRA should refer to the FY23 NFRP Neurofibromatosis Research Academy - Scholar Award program announcement (HT9425-23-NFRP-NFRA-SA). Note: An invited oral presentation is a requirement for application review of the NFRP NFRA-LA, as described in Section II.D.2.b, Full Application Submission Content.

Deadlines:
• Required Pre-Application Submission Deadline:  Aug. 11, 2023
• Application Submission Deadline: Aug. 25, 2023

Agency Website

Areas of Interest

Areas of Emphasis: The FY23 NFRP strongly encourages research applications that specifically address the critical needs of the NF community in one or more of the Areas of Emphasis listed below. All applications are also encouraged to include materials and data from diverse populations in their research.

• NF2 and Schwannomatosis-related areas (e.g., hearing, balance, schwannoma, ependymoma, meningioma, LZTR1, SMARCB1)

• Endpoint validation, biomarker discovery, and technological innovation for assessments

• Application of data science

• Non-tumor manifestations not limited to: o Pain o Cognitive manifestations o Sleep

• Heterogeneity of NF-related phenotypes

• Genetics, genomics, epigenetics, systems biology, metabolomics, or similar approaches

• Preclinical efficacy studies

• Target identification and drug discovery

• Nutritional, environmental, and other modifiers of NF

• Health services research

Eligibility Requirements

Academy Director and Deputy Director: • Must be an independent, established neurofibromatosis researcher at or above the level of associate professor or equivalent. • Must have neurofibromatosis research funding (past and/or present). • Must have a record of neurofibromatosis publications in peer-reviewed journals. • Must demonstrate a commitment of at least 25% effort towards leading the Academy’s activities. • May be a research- or physician-scientist.

Amount

$1,300,000

Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY23 NFRP NFRA - LA Award should not exceed $1.3M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type

Award
Grant

Eligibility

Faculty

Category

Environmental & Life Sciences
Medical
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

August 11, 2023