Congressionally Directed Medical Research Programs (CDMRP) -- Peer Reviewed Cancer Research Program (PRCRP) -- Transformative Breast Cancer Consortium Award

Funding Agency:
Department of Defense

The Transformative Breast Cancer Consortium Award is designed to support collaborations and ideas that will transform the lives of individuals with, and/or at risk for, breast cancer and will significantly accelerate progress toward ending breast cancer. Applicants must bring together different perspectives to develop new paradigms that will solve fundamental yet overarching problems in breast cancer. This award requires a team-based approach by a consortium of exceptional researchers and advocates, whose collaborative efforts will make a transformative impact in breast cancer. The transformation intended by the consortium must be in people’s lives, and not in the healthcare or research system.

The consortium should have at least four, but no more than five, project teams, each investigating different projects under a central hypothesis. No more than two project teams may be based at one institution. Each team’s work must be integrated within the consortium so that every component is working toward the consortium’s central hypothesis. Note: This award is not intended to replace, supplement, duplicate, or compete with other collaborative research efforts, such as the National Cancer Institute (NCI) Specialized Programs of Research Excellence (SPOREs), and it should not represent a collection of related Program Project grants or subprojects.

The proposed consortium’s overall work is expected to be innovative. In addition, the Transformative Breast Cancer Consortium Award will include funds for “seed projects” to pursue brand new, high-risk/high-reward concepts that arise from the work, during the award period.

• Pre-Application Deadline: August 3, 2022
• Invitation to Submit an Application: Sep. 2022
• Application Submission Deadline:  Nov. 2, 2022

Agency Website

Areas of Interest

Considering the current breast cancer landscape and the BCRP’s mission, all FY22 BCRP Transformative Breast Cancer Consortium Award applications must address at least one of the following overarching challenges unless adequate justification for exception is provided.* • Prevent breast cancer (primary prevention) • Identify determinants of breast cancer initiation, risk, or susceptibility • Distinguish deadly from non-deadly breast cancers • Conquer the problems of overdiagnosis and overtreatment • Identify what drives breast cancer growth; determine how to stop it • Identify why some breast cancers become metastatic • Determine why/how breast cancer cells lie dormant for years and then re-emerge; determine how to prevent lethal recurrence • Revolutionize treatment regimens by replacing them with ones that are more effective, less toxic, and impact survival • Eliminate the mortality associated with metastatic breast cancer

Eligibility Requirements

Independent investigators at all academic levels (or equivalent) are eligible to be named as a Consortium Director or Project Team PI on an application.

The Consortium Director is required to commit and maintain at least 25% level of time and effort during the award period to direct and manage the consortium and to lead their own project team. 

An investigator may be named as Consortium Director on only one pre-application. There are no limits on the number of pre-applications for which an investigator may be named as a Project Team PI for this Transformative Breast Cancer Consortium Award.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY22 BCRP Transformative Breast Cancer Consortium Award will not exceed $25M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

August 3, 2022