Congressionally Directed Medical Research Programs (CDMRP) -- Peer Reviewed Orthopaedic Research Program (PRORP) -- Clinical Trial Award

Funding Agency:
Department of Defense

The PRORP CTA is intended to support the rapid implementation of clinical trials with the potential to have a major impact on military combat-related orthopaedic injuries or non-battle injuries that significantly impact unit readiness and return to duty/work rates. Applicants are encouraged to address how the proposed research will support patient care closer to the point of injury and/or allow patients to more quickly return to duty/work. 

The FY19 PRORP CTA differs from the FY19 PRORP Clinical Translational Research Award (CTRA) in that the CTRA allows for clinical research projects, whereas the CTA is restricted to clinical trials only. 


• Required Pre-Application Deadline:  June 26, 2019

• Application Submission Deadline:  September 18, 2019

Agency Website

Areas of Interest

All applications must address one of the following FY19 PRORP CTA Focus Areas. Selection of the appropriate Focus Area is the responsibility of the applicant. Studies that propose nominal or iterative advancements are not encouraged.

1. Limb Stabilization and Protection: Clinical assessment of rapid limb stabilization and novel wound protectants for severely wounded limbs to enable transport at the point of need.

2. Retention on Duty Strategies: Validation of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty for common combat-related musculoskeletal injuries. (Biomarker studies are excluded.)

3. Translation of Early Findings: Translation of early research findings in the orthopaedic surgical care topic areas listed below to move the research toward clinical trials and clinical practice. a. Volumetric Muscle Loss: Techniques to regenerate functional, innervated muscle units in treatment of volumetric muscle loss. b. Compartment Syndrome: Treatment strategies to improve current diagnoses for compartment syndrome. c. Soft Tissue Trauma: Strategies to develop and/or identify musculoskeletal extremity soft tissue trauma treatments (for anterior cruciate ligament [ACL] or shoulder instability only) to optimize return to duty, work, or reintegration

Eligibility Requirements

Independent investigators at all academic levels (or equivalent) may be named by the organization as the PI on the application.



Amount Description

The anticipated total costs budgeted for the entire period of performance for an FY19 PRORP CTA will not exceed $2.5M (Funding Level 1) or $3.0M (Funding Level 2). Refer to Section II.D.5, Funding Restrictions, for detailed funding information. 

Funding Type



Junior Faculty
Medical Fellow/Resident
Post Doctoral Fellows


Engineering and Physical Sciences
Medical - Clinical Science

External Deadline

June 26, 2019