Congressionally Directed Medical Research Programs (CDMRP) -- Peer Reviewed Orthopaedic Research Program (PRORP) -- Clinical Translational Research Award

Funding Agency:
Department of Defense

The PRORP CTRA is intended to support high-impact and/or new/emerging clinical research that may or may not be ready for a full-scale randomized controlled clinical trial. Projects should demonstrate potential to impact the standard of care, both immediate and long-term, as well as contribute to evidence-based guidelines for the evaluation and care of military, Veteran, and all patients with orthopaedic injuries.

  • One goal of the FY19 PRORP CTRA is to translate current and emerging techniques and interventions into the clinical space to better serve military patients closer to the point of injury and in a delayed evacuation scenario. The health, functional abilities, and quality of life of individuals who have sustained an orthopaedic injury should be considered.
  • Another goal is to identify the most effective diagnosis, treatment, rehabilitation, and prevention options available to support critical decision-making for patients, clinicians, other caregivers, and policymakers.

The FY19 PRORP CTRA differs from the FY19 PRORP Clinical Trial Award (CTA) in that the CTRA allows for clinical research projects, whereas the CTA is restricted to clinical trials only. Funding from this award mechanism must support clinical research; animal research is not allowed. The proposed studies may be interventional and may involve some retrospective data analysis. Note that purely retrospective or database-related research is not allowed under this funding opportunity. Small pilot clinical trials with human subjects are also allowable. 


• Required Pre-Application Deadline:  June 26, 2019

• Application Submission Deadline:  September 18, 2019

Agency Website

Areas of Interest

All applications must address one of the following FY19 PRORP CTRA Focus Areas. Selection of the appropriate Focus Area is the responsibility of the applicant. Studies that propose nominal or iterative advancements are not encouraged.

1. Retention on Duty Strategies: Development and/or optimization of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty for common combat-related musculoskeletal injuries. (Biomarker studies are excluded.)

2. Tissue Regeneration Therapeutics: Development of advanced tissue regeneration therapeutics in nerve, muscle, and/or composite tissue for the restoration of traumatically injured extremities. (Isolated bone tissue engineering studies are excluded.) 

Eligibility Requirements

Independent investigators at all academic levels (or equivalent) are eligible to submit. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization



Amount Description

The anticipated total costs budgeted for the entire period of performance for an FY19 PRORP CTRA award will not exceed $2M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. 

Funding Type



Junior Faculty
Medical Fellow/Resident
Post Doctoral Fellows


Medical - Clinical Science
Medical - Translational

External Deadline

June 26, 2019