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Congressionally Directed Medical Research Programs (CDMRP) -- Tuberous Sclerosis Complex Research Program -- Synergistic Idea Development Award
The TSCRP Synergistic Idea Development Award mechanism is being offered for the first time in FY16. The Synergistic Idea Development Award supports new or existing partnerships between two or three Principal Investigators (PIs) who should utilize their complementary and synergistic perspectives to significantly accelerate advances in TSC research to support the TSCRP vision to lessen the impact of TSC. Although groundbreaking research often involves a degree of risk, applications should be based on a sound scientific rationale that is established through logical reasoning, critical review and analysis of the literature, and preliminary data relevant to TSC and the proposed project. Research deemed innovative may represent a new paradigm, challenge current paradigms, explore existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative.
The Synergistic Idea Development Award mechanism requires multiple investigators in a wide spectrum of disciplines including, but not limited to, basic science, engineering, bioinformatics, population science, translational research, and clinical research to jointly design a single project. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI(s) will be identified as a Partnering PI(s). Initiating and Partnering PIs each have different submission requirements, as described in Section II; however, all PIs should contribute significantly to the development and execution of the proposed research project. If recommended for funding, each PI will receive his/her own award.
The research project must be supported by the unique expertise, experience, and abilities of each PI, and it must clearly define the synergistic components (i.e., leveraging disciplines, expertise, or critical resources) that will significantly advance the project such that the research outcomes as a whole will be realized rapidly and efficiently and could not otherwise be accomplished through independent efforts of a single PI. Multidisciplinary projects are encouraged, and multiinstitutional projects are allowed. Each proposed study must include clearly stated plans for interactions among all PIs and organizations involved. The plans must include communication, coordination of research progress and results, and data transfer. Additionally, multi-institutional applications must provide an intellectual property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.
• Pre-Application Submission Deadline: July 1, 2016
• Application Submission Deadline: July 18, 2016
Areas of Interest
The mission of the FY16 TSCRP is to encourage innovative research aimed at understanding the pathogenesis, and preventing and treating the manifestations of TSC. Within this context, the FY16 TSCRP encourages applications to address one or more of the following Focus Areas:
• Understanding phenotypic heterogeneity in TSC
• Gaining a deeper knowledge of TSC signaling pathways and the cellular consequences of TSC deficiency
• Improving TSC disease models
• Developing clinical biomarkers for TSC
• Facilitating therapeutics and clinical trials research
If the proposed research project does not address one or more of the FY16 Focus Areas, justification that the proposed research project addresses an important problem or unmet need related to TSC research and/or patient care should be provided.
Each PI must be at or above the level of Assistant Professor or equivalent.
• The maximum period of performance is 3 years. • The anticipated combined direct costs budgeted for the entire period of performance for the Initiating PI and the Partnering PI’s/PIs’ applications will not exceed $750,000. The combined total direct costs of the Initiating PI and the Partnering PI’s/PIs’ awards will not exceed $750,000 direct costs. If the Initiating PI’s or Partnering PI’s/PIs’ budgets contain a subaward (or multiple subawards), all direct and indirect costs of the subaward(s) must be included in the direct costs of the primary award. Collaborating organizations should budget associated indirect costs in accordance with each organization’s negotiated rate. The combined budgeted direct costs approved by the Government will not exceed $750,000 or use an indirect rate exceeding each organization’s negotiated rate. • All direct and indirect costs of any subaward (subgrant or subcontract) must be included in the total direct costs of the primary award. • The applicants may together request the entire maximum funding amount for a project that may have a period of performance less than the maximum 3 years. • A separate award will be made to each PI’s organization. • The PIs are expected to be equal partners in the research, and direct cost funding should be divided accordingly, unless otherwise warranted and clearly justified