The Clinical Translational Research Award supports studies that will move promising, wellfounded preclinical and/or clinical research findings closer to clinical application, including diagnosis, prognosis, or treatment of TSC. Projects supported by this award mechanism may include studies moving from preclinical to clinical research and/or the reverse, analyzing human anatomical substances and/or data associated with clinical trials (such as correlative studies). Studies advancing clinical trial readiness through development of biomarkers, clinical endpoints, and validation of PK/PD are of particular interest to the FY20 TSCRP. In addition, pilot clinical trials, including behavioral interventions, are encouraged.
Preference will be given to studies that involve human samples, or patients, or that leverage existing clinical data and/or ongoing clinical studies. Preclinical studies may be appropriate but must include a clinical component. Projects that are exploratory and/or strictly animal research will not be considered for funding.
Deadlines:
• Pre-Application Deadline: June 18, 2020
• Application Submission Deadline: July 9, 2020
The mission of the FY20 TSCRP is to fund exploratory, pioneering, and transformative science that promotes discoveries in TSC, from mechanistic insights to clinical application across the lifespan, by supporting new ideas and investigators for the benefit of Service members, their beneficiaries, and the American public. Within this context, the FY20 TSCRP encourages applications in mechanistic and patient-centered studies that focus on one of the following Focus Areas:
If the proposed research project does not address one or more of the FY20 TSCRP Focus Areas, justification that the proposed research project addresses an important problem or unmet need related to TSC research and/or patient care should be provided.
Independent investigators at or above the level of Assistant Professor (or equivalent) are eligible to be named as a PI on applications. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization. The CDMRP encourages all PIs to participate in a digital identifier initiative through Open Researcher and Contributor ID, Inc. (ORCID). Registration for a unique ORCID identifier can be done online at https://orcid.org/.
The anticipated direct costs budgeted for the entire period of performance for an FY20 TSCRP Clinical Translational Research Award will not exceed $600,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
