Congressionally Directed Medical Research Programs -- Chronic Pain Management Research Program -- Translational Research Award

Funding Agency:
Department of Defense

The intent of the FY22 CPMRP TRA is to support translational research that will accelerate the movement of evidence-based ideas in chronic pain management research into clinical applications, such as healthcare products, technologies, clinical practice guidelines, and/or models of care. TRA applications should explain how the proposed work will inform the development, refinement, and/or revision of existing standards of care, recommendations, or guidelines for managing chronic pain. Studies seeking to advance new and novel opioid-based therapeutic interventions do not meet the intent of the award mechanism and will not be selected for funding. Studies seeking to understand and reduce opioid utilization in chronic pain management within the context of current prescribing practices are acceptable.


  • Required Pre-Application Deadline:   July 12, 2022
  • Invitation to Submit an Application: Aug. 2022
  • Application Submission Deadline:  Oct. 13, 2022

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications must address at least one of the FY22 CPMRP TRA Focus Areas. Selection of the appropriate focus area is the responsibility of the applicant.

• Implementation science (for evidence-based, efficacious interventions to manage or prevent chronic pain) o Unique barriers for Service Members, Veterans, and beneficiaries, including at-risk subpopulations o Self-management and service-of-care models o Interventions to prevent chronification of pain

• Comparative effectiveness (for evidence-based, efficacious interventions to manage or prevent chronic pain) o Multimodal, integrative, and combination therapies o Relationships between comorbidities and pain o Preventing chronification of pain

• Observational studies related to chronic pain o Predictor studies of poor outcomes from long-term opioid use o Predictors of pain chronification o Evaluation of health care use patterns (e.g., systems, interventions, treatments) o Relationships between comorbidities and pain

Additionally, the incorporation of one or more of the following into the proposed research approaches is encouraged but not required: • Pain informatics • Pragmatic approaches • Patient expectations, preference, and goals of treatment at point of care • Multiple ecological levels of stakeholder engagement in the study design with human participants • High prevalence in military populations including Service Members, Veterans, and beneficiaries. • Established models of pain assessments that include pain interference in emotional and physical functioning

Eligibility Requirements

Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI or Partnering PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY22 CPMRP TRA will not exceed $1.4M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information

Funding Type



Junior Faculty


Medical - Clinical Science
Medical - Translational

External Deadline

July 12, 2022