Congressionally Directed Medical Research Programs -- Chronic Pain Management Research Program -- Investigator-Initiated Research Award

Funding Agency:
Department of Defense

The intent of the FY19 CPMRP IIRA is to support studies that have the potential to make significant advances in research, patient care, and/or quality of life in the FY19 CPMRP IIRA Focus Area, Chronification of Pain. Through understanding the determinates of transition from acute to chronic pain and development of therapies that block the process of chronification, the CPMRP seeks to prevent the manifestation of chronic pain and thus reduce the population requiring pain management interventions. IIRA applications may involve any phase of basic, translational, and clinically oriented research, including studies in animal models, research with human anatomical substances, and research with human subjects, as well as ancillary studies associated with an existing clinical trial; however, this award may not be used to conduct clinical trials. Multidisciplinary collaborations and innovative approaches are encouraged.


  • Pre-Application Deadline:   Sep. 13, 2019
  • Invitation to Submit an Application: Oct. 2019
  • Application Submission Deadline:  Dec. 6, 2019

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications must address the FY19 CPMRP Investigator-Initiated Research Award (IIRA) Focus Area, Chronification of Pain (i.e., the transition of acute pain to chronic pain) and one or more of the following related Knowledge Gaps.

• Understanding mechanisms and developing models for studying the transition from acute to chronic pain following trauma either physical or psychological

• Development of non-opioid therapies to prevent and treat chronification

• Identification of risk factors or biomarkers for patients at risk of chronification including atrisk sub-populations

Additionally, the incorporation of pain informatics, pragmatic approaches, and patient expectations, preference, and goals of treatment at point of care in research approaches is encouraged.

Eligibility Requirements

Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY19 CPMRP IIRA will not exceed $900,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Clinical Science
Medical - Translational

External Deadline

September 13, 2019