Congressionally Directed Medical Research Programs -- Chronic Pain Management Research Program -- Investigator-Initiated Research Award

Funding Agency:
Department of Defense

The intent of the FY22 CPMRP is to support studies that have the potential to make significant advances in the research, patient care and/or quality of life in the FY22 CPMRP IIRA Focus Areas. IIRA applications may involve basic, translational, and clinically oriented research, including studies in animal models, research with human anatomical substances, and research with human subjects, as well as correlative studies associated with an existing clinical trial; however, this award may not be used to conduct clinical trials. Multidisciplinary collaborations and innovative approaches are encouraged. Studies seeking to advance new and novel opioidbased therapeutic interventions do not meet the intent of the award mechanism and will not be selected for funding. Studies seeking to understand and reduce opioid utilization in chronic pain management within the context of current prescribing practices are acceptable.


  • Required Pre-Application Deadline:   July 12, 2022
  • Invitation to Submit an Application: Aug. 2022
  • Application Submission Deadline:  Oct. 13, 2022

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications must address at least one of the FY22 CPMRP Investigator-Initiated Research Award (IIRA) Focus Areas. Selection of the appropriate focus area is the responsibility of the applicant.

Chronification of pain ○ Understanding mechanisms of, and developing models for studying, the transition from acute to chronic pain following trauma either physical and/or psychological ○ Development of mechanistically justified therapies to prevents and treat chronification ○ Identifying risk or protective factors or biomarkers for patients susceptible to chronification, including relevant subpopulations ○ Investigating relationships between pain and its co-morbidities that can contribute to the development/progression of chronic pain

Effectiveness or observational studies of novel treatments or untested techniques/approaches/pathways to chronic pain management ○ Pilot/preliminary studies ○ Potential clinical effectiveness

Development of non-opioid therapies and methods of the treatment of chronic pain ○ Novel non-opioid pharmacological solutions ○ Devices that treat chronic pain directly ○ Devices that improve the administration of non-opioid analgesics

Additionally, the incorporation of one or more of the following into the proposed research approaches is encouraged but not required:  Pain informatics  Pragmatic approaches  Patient expectations, preference, and goals of treatment at point of care  Multiple ecological levels of stakeholder engagement in the study design with human participants  High prevalence in military populations including Service Members, Veterans, and beneficiaries.  Established models of pain assessments that include pain interference in emotional and physical functioning

Eligibility Requirements

Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI or Partnering PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY22 CPMRP IIRA will not exceed $900,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

July 12, 2022