Congressionally Directed Medical Research Programs -- Chronic Pain Management Research Program -- Investigator-Initiated Research Award

Funding Agency:
Department of Defense

The intent of the FY20 CPMRP IIRA is to support studies that have the potential to make significant advances in research, patient care, and/or quality of life in the FY20 CPMRP IIRA Focus Areas. IIRA applications may involve any phase of basic, translational, and clinically oriented research, including studies in animal models, research with human anatomical substances, and research with human subjects, as well as ancillary studies associated with an existing clinical trial; however, this award may not be used to conduct clinical trials. Multidisciplinary collaborations and innovative approaches are encouraged.


  • Pre-Application Deadline:   Aug. 7, 2020
  • Invitation to Submit an Application: Sep. 2020
  • Application Submission Deadline:  Nov. 6, 2020

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications must address one of the FY20 CPMRP Investigator-Initiated Research Award (IIRA) Focus Areas. Selection of the appropriate Focus Area is the responsibility of the applicant.

• Chronification of pain (i.e., the transition of acute pain to chronic pain) o Understanding mechanisms of, and developing models for studying, the transition from acute to chronic pain following trauma either physical and/or psychological o Development of mechanistically justified therapies to prevent and treat chronification o Identification of risk or protective factors or biomarkers for patients susceptible to chronification including relevant subpopulations 

• Development of novel non-µ-opioid receptor-targeted therapies for the treatment of chronic pain o Novel non-opioid pharmacological solutions o Devices that treat chronic pain directly or those that improve the administration of nonopioid analgesics o Complementary and integrative health non-pharmacological interventions

Additionally, the incorporation of the following into the proposed research approaches is encouraged but not required: • Pain informatics • Pragmatic approaches • Patient expectations, preference, and goals of treatment at point of care • Multiple ecological levels and stakeholder engagement in study designs with human participants • Chronic pain conditions with high prevalence in military populations • Established models of pain assessment that include pain interference in emotional and physical functioning

Eligibility Requirements

Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY20 CPMRP IIRA will not exceed $900,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Clinical Science
Medical - Translational

External Deadline

August 7, 2020