Congressionally Directed Medical Research Programs -- Chronic Pain Management Research Program -- Investigator-Initiated Research Award

Funding Agency:
Department of Defense

The intent of the FY21 CPMRP IIRA is to support studies that have the potential to make significant advances in research, patient care, and/or quality of life in the FY21 CPMRP IIRA Focus Areas. IIRA applications may involve basic, translational, and clinically oriented research, including studies in animal models, research with human anatomical substances, and research with human subjects, as well as correlative studies associated with an existing clinical trial; however, this award may not be used to conduct clinical trials. Multidisciplinary collaborations and innovative approaches are encouraged. Studies seeking to advance new and novel opioid-based therapeutic interventions do not meet the intent of the award mechanism and may be withdrawn. Studies seeking to understand and reduce opioid utilization in chronic pain management within the context of current prescribing practices are acceptable.


  • Required Pre-Application Deadline:   July 30, 2021
  • Invitation to Submit an Application: Sep. 2021
  • Application Submission Deadline:  Nov. 12, 2021

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications must address at least one of the FY21 CPMRP IIRA Focus Areas. Selection of the appropriate focus area is the responsibility of the applicant.

• Chronification of pain ○ Understanding mechanisms of, and developing models for studying, the transition from acute to chronic pain following trauma either physical and/or psychological ○ Development of mechanistically justified therapies to prevent and treat chronification ○ Identifying risk or protective factors or biomarkers for patients susceptible to chronification, including relevant subpopulations ○ Investigating relationships between comorbidities and pain that can contribute to the development/progression of chronic pain

• Development of non-opioid therapies and methods for the treatment of chronic pain o Novel non-opioid pharmacological solutions o Devices that treat chronic pain directly or those that improve the administration of nonopioid analgesics

• Effectiveness or observational studies of novel or untested techniques/approaches/pathways to chronic pain management ○ Pilot/preliminary studies ○ Potential clinical effectiveness o Complementary and integrative health or other non-pharmacological interventions

Eligibility Requirements

Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI or Partnering PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY21 CPMRP IIRA will not exceed $900,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

July 30, 2021