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Congressionally Directed Medical Research Programs -- Defense Medical Research and Development Program (DMRDP) -- Battlefield Wound Management and Infection Research Award
The DMRDP BWMIR Award seeks to enhance combat traumatic wound care capabilities throughout the medical continuum of care, which may be complicated by combat operations, limited resources, austere conditions, and/or mass casualty events. The intent of the FY22 DMRDP BWMIR Award is to support research that will increase the understanding of complex wound physiology and infection control in order to support future application and maturation of products, technologies, and clinical practice. Research that advances and/or repurposes existing solutions and has the potential to be broadly applicable is advantageous, but not required. Additionally, submissions may present advances benefiting military health and medicine as well as the general public.
Applicants may leverage existing resources in translational research to address high-impact research ideas or unmet needs to enable the delivery of life-saving care to the Warfighter during prolonged and en route care in austere and combat environments. For this award mechanism, the definition of “leveraging” is as follows: carrying out a research project based on existing resources in order to amplify potential gains in knowledge or accelerate technical maturity. Research of interest may include knowledge products, i.e., “knowledge resulting from research with the potential to improve individual or public health,”3 and solutions that can accelerate the introduction of military-relevant health products or technologies into clinical and/or operational use. Projects should take into consideration the varied expertise levels of targeted medical providers, available resources, and the possible diverse environmental conditions in combat situations. Proposal/application submissions are encouraged to include characteristics relevant to military use in the pre-hospital, combat operational setting. Submissions that propose solutions to advance civilian trauma care are not precluded, since civilian trauma and trauma care in the military are mutually influential and may be co-occurring in certain situations.
- Required Pre-Proposal/Pre-Application Submission Deadline: October 20, 2022
- Proposal/Application Submission Deadline: November 16, 2022
Areas of Interest
The DMRDP BWMIR Award will support the research and development of materiel and knowledge products to address critical gaps in combat traumatic wound management and control of infection, in operational environments. Specifically, research that supports the understanding of physiological processes of combat-associated traumatic wounds and infections in preclinical and clinical models represents a key priority for the JPC-2/MIDRP and JPC-6/CCCRP. The Focus Areas below broadly describe areas of particular interest for funding under the FY22 DMRDP BWMIR. To meet the intent of the award mechanism, proposals/applications submitted to the FY22 DMRDP BWMIR must address at least one of the FY22 DMRDP BWMIR Focus Areas listed below. Research not aligned to at least one Focus Area will not be considered for funding. Selection of the appropriate FY22 DMRDP BWMIR Focus Area(s) is the responsibility of the applicant.
- Understanding appropriate wound prophylaxis/empiric treatment strategies throughout continuum of care, regardless of injury status, through preclinical and clinical studies to inform clinical practice guidelines for: o Managing hemorrhagic shock/super-massive transfusion, traumatic limb ischemia (secondary to vascular disruption or tourniquet use), complex soft tissue injury/blast injury, open fracture, and/or frost bite, including evaluation of antimicrobial dosing and tissue penetration studies. o Expanding the understanding of antibiotic use in tissue injury (e.g., systemic versus topical), especially in the context of hemorrhage/resuscitation, blast, and/or delayed evacuation times
- Understanding combat traumatic wound physiology and wound progression through preclinical and clinical studies to inform clinical practice guidelines and standard of care efficacy and gaps.
- Optimizing prolonged care management of penetrating torso injury by developing solutions for prevention/management of deep space infections (e.g., bacterial or fungal) and delays in care of penetrating abdominal injury.
- Development of analysis and decision support tools to guide traumatic combat wound care and casualty management to triage, prevent and/or treat infections. Examples include: o Technologies to determine the types of wound infections at risk of progression to complications and sepsis; o Tools to evaluate tissue status before devitalization; and o Guided triage/intervention techniques to be used by front-line providers at early stages of care.
Independent investigators at all academic levels (or equivalent) are eligible to be named by the organization as the PI in the proposal/application. There are no limitations on the number of proposals/applications for which an investigator may be named as a PI. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.
Funding Level 1: Preclinical research studies supported by substantial preliminary or published data. Clinical research and clinical trials are not allowed. Anticipated total costs of Funding Level 1 will not exceed $1.2 million (M).
Funding Level 2: Studies including clinical research or clinical trials supported by substantial preliminary or published data. Research proposed under Funding Level 2 may include some preclinical activities, but must include some aspect of clinical research or a clinical trial. Anticipated total costs of Funding Level 2 will not exceed $2.2M.